MUTS_STRA1
ID MUTS_STRA1 Reviewed; 858 AA.
AC Q3JYM3;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SAK_2040;
OS Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC
OS SS700).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=205921;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27591 / A909 / CDC SS700;
RX PubMed=16172379; DOI=10.1073/pnas.0506758102;
RA Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D.,
RA Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T.,
RA Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D.,
RA Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R., Brinkac L.M.,
RA Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H.,
RA Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D.,
RA Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O.,
RA Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L.,
RA Wessels M.R., Rappuoli R., Fraser C.M.;
RT "Genome analysis of multiple pathogenic isolates of Streptococcus
RT agalactiae: implications for the microbial 'pan-genome'.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000114; ABA44611.1; -; Genomic_DNA.
DR RefSeq; WP_001118379.1; NC_007432.1.
DR AlphaFoldDB; Q3JYM3; -.
DR SMR; Q3JYM3; -.
DR KEGG; sak:SAK_2040; -.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OMA; TPMMAQY; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..858
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224409"
FT BINDING 603..610
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 858 AA; 96992 MW; DECA2AC9085CF204 CRC64;
MAKPTISPGM QQYLDIKENY PDAFLLFRMG DFYELFYDDA VKAAQILEIS LTSRNKNAEK
PIPMAGVPYH SAQQYIDVLV ELGYKVAIAE QMEDPKKAVG VVKREVVQVV TPGTVVESTK
PDSANNFLVA IDSQDQQTFG LAYMDVSTGE FQATLLTDFE SVRSEILNLK AREIVVGYQL
TDEKNHLLTK QMNLLLSYED ERLNDIHLID EQLTDLEISA AEKLLQYVHR TQKRELSHLQ
KVVHYEIKDY LQMSYATKNS LDLLENARTS KKHGSLYWLL DETKTAMGTR MLRTWIDRPL
VSMNRIKERQ DIIQVFLDYF FERNDLTESL KGVYDIERLA SRVSFGKANP KDLLQLGQTL
SQIPRIKMIL QSFNQPELDI VVNKIDTMPE LESLINTAIA PEAQATITEG NIIKSGFDKQ
LDNYRTVMRE GTGWIADIEA KERAASGIGT LKIDYNKKDG YYFHVTNSNL SLVPEHFFRK
ATLKNSERYG TAELAKIEGE VLEAREQSSN LEYDIFMRVR AQVESYIKRL QELAKTIATV
DVLQSLAVVA ENHHYVRPKF NDEHQIKIKN GRHATVEKVM GVQEYIPNSI YFDSQTDIQL
ITGPNMSGKS TYMRQLALTV IMAQMGGFVS ADEVDLPVFD AIFTRIGAAD DLISGQSTFM
VEMMEANQAV KRASDKSLIL FDELGRGTAT YDGMALAQSI IEYIHDRVRA KTMFATHYHE
LTDLSEQLTR LVNVHVATLE RDGEVTFLHK IESGPADKSY GIHVAKIAGL PIDLLDRATD
ILSQLEADAV QLIVSAPQEA VTADLNEELD SEKQQGQLSL FEEPSNAGRV IEELEAIDIM
NLTPMQAMNA IFDLKKLL