ID   MUTS_STRA5              Reviewed;         858 AA.
AC   Q8DWW1;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; Synonyms=hexA;
GN   OrderedLocusNames=SAG2101;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE009948; AAN00959.1; -; Genomic_DNA.
DR   RefSeq; NP_689086.1; NC_004116.1.
DR   RefSeq; WP_001118377.1; NC_004116.1.
DR   AlphaFoldDB; Q8DWW1; -.
DR   SMR; Q8DWW1; -.
DR   STRING; 208435.SAG2101; -.
DR   EnsemblBacteria; AAN00959; AAN00959; SAG2101.
DR   KEGG; sag:SAG2101; -.
DR   PATRIC; fig|208435.3.peg.2104; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115145"
FT   BINDING         603..610
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  97079 MW;  EB7FB2EE0153EE5F CRC64;
     MAKPTISPGM QQYLDIKENY PDAFLLFRMG DFYELFYDDA VKAAQILEIS LTSRNKNAEK
     PIPMAGVPYH SAQQYIDVLV ELGYKVAIAE QMEDPKKAVG VVKREVVQVV TPGTVVESTK
     PDSANNFLVA IDSQDQQTFG LAYMDVSTGE FQATLLTDFE SVRSEILNLK AREIVVGYQL
     TDEKNHLLTK QMNLLLSYED ERLNDIHLID EQLTDLEISA AEKLLQYVHR TQKRELSHLQ
     KVVHYEIKDY LQMSYATKNS LDLLENARTS KKHGSLYWLL DETKTAMGTR MLRTWIDRPL
     VSMNRIKERQ DIIQVFLDYF FERNDLTESL KGVYDIERLA SRVSFGKANP KDLLQLGQTL
     SQIPRIKMIL QSFNQPELDI IVNKIDTMPE LESLINTAIA PEAQATITEG NIIKSGFDKQ
     LDNYRTVMRE GTGWIADIEA KERAASGIGT LKIDYNKKDG YYFHVTNSNL SLVPEHFFRK
     ATLKNSERYG TAELAKIEGE MLEAREQSSN LEYDIFMRVR AQVESYIKRL QELAKTIATV
     DVLQSLAVVA ENYHYVRPKF NDQHQIKIKN GRHATVEKVM GVQEYIPNSI YFDSQTDIQL
     ITGPNMSGKS TYMRQLALTV IMAQMGGFVS ADEVDLPVFD AIFTRIGAAD DLISGQSTFM
     VEMMEANQAV KRASDKSLIL FDELGRGTAT YDGMALAQSI IEYIHDRVRA KTMFATHYHE
     LTDLSEQLTR LVNVHVATLE RDGEVTFLHK IESGPADKSY GIHVAKIAGL PIDLLDRATD
     ILSQLEADAV QLIVSPSQEA VTADLNEELD SEKQQGQLSL FEEPSNAGRV IEELEAIDIM
     NLTPMQAMNA IFDLKKLL