ID   MUTS_STRE4              Reviewed;         851 AA.
AC   C0MAS5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SEQ_2161;
OS   Streptococcus equi subsp. equi (strain 4047).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4047;
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F.,
RA   Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M.,
RA   Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A.,
RA   Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C.,
RA   Maskell D.J., Parkhill J., Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; FM204883; CAW95529.1; -; Genomic_DNA.
DR   RefSeq; WP_015898667.1; NC_012471.1.
DR   AlphaFoldDB; C0MAS5; -.
DR   SMR; C0MAS5; -.
DR   EnsemblBacteria; CAW95529; CAW95529; SEQ_2161.
DR   KEGG; seu:SEQ_2161; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001365; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192203"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95066 MW;  EDCD1244522BDD4C CRC64;
     MAKANVSPGM QQYLDIKKDY PDAFLLFRMG DFYELFYEDA VKAAQILEIG LTSRNKNADN
     PIPMAGVPYH SVQQYIDVLI DLGHKVAIAE QMEDPKQAVG VVKREVVQVI TPGTAVDSSR
     PDSPNNFLVA VDFDGKAYGL SYMDVSTGEF FATDLADFAS VKSEIQNLKA KEVLLGFELS
     EEEQAILVKQ LNLLLSFEMT ALEDSPLIDH QLTAVELSAA GKLLHYVHQT QLRELSHLQA
     LVHYDIKDYL QMSYATKSSL DLLENARTGK KHGSLYWLLD ETKTAMGMRL LRAWIDRPLV
     TSEAILERQE IIQVFLNAFI ERTDLSDSLK GVYDIERLSS RVSFGKANPK DLLQLGHTLA
     KVPYIKAILE AFNSPYLDKL VNQIDTLPEL EHLIRSAIDP DAPATINEGN IIRTGFDERL
     DHYRKVMREG TGWIADIETK ERQASGISNL KIDYNKKDGY YFHVTNSNLG MVPDHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESSSL EYDIFMRIRA QVETYIDRLQ QLAKALATVD
     VLQSLAVVAE KNHYVRPLFN QESKIAIDNG RHAVVEKVLG VQEYIPNSIS FGPQTSIQLI
     TGPNMSGKST YMRQLALTVI MAQIGSFVAA ESASLPLFDA IFTRIGAADD LISGQSTFMV
     EMMEANHAIK RATPHSLILF DELGRGTATY DGMALAQSII EYIHDRVGAK TMFATHYHEL
     TELSTKLTKL VNVHVATLEK DGNVTFLHKI AEGPADKSYG IHVARIAGLP EDLLARADTV
     LTKLEAQSQA RESVLSTTEV RETQQLANQQ LSLFTDDGSS SEIIKRLESV DVMNLTPIQA
     MTVLYELKKL L