ID   MUTS_STRGC              Reviewed;         847 AA.
AC   A8AZU4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SGO_2056;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/jb.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000725; ABV10378.1; -; Genomic_DNA.
DR   RefSeq; WP_012131025.1; NC_009785.1.
DR   AlphaFoldDB; A8AZU4; -.
DR   SMR; A8AZU4; -.
DR   STRING; 467705.SGO_2056; -.
DR   EnsemblBacteria; ABV10378; ABV10378; SGO_2056.
DR   KEGG; sgo:SGO_2056; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..847
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075567"
FT   REGION          788..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   847 AA;  95246 MW;  71E5B5FCF59D2494 CRC64;
     MATEKISPGM QQYLDIKKDY QDAFLLFRMG DFYELFYEDA VNAAQILEIA LTSRNKNSEN
     PIPMAGVPYH SAQQYIDVLI ESGYKVAIAE QMEDPKQAVG VVKREVVQVI TPGTVVDSSK
     PVGENNFLVA LDRQEQAYGL AYMDLATGEF QVTSLADFDQ ACGEIRNLRA REVVVGYCLS
     EDEQQILSKQ MNLLLSEVEE AMEDVQLLGD ELSSLEKQTA GKLLAYVFQT QMRELSHLKK
     VHHYEIKDFL QMDYATKTSL DLTENARTGK KHGSLFWLMD ETKTAMGGRL LRSWIQHPLI
     DKGRIIKRQD VVQVFLDYFF ERSDLADSLK GVYDIERLVS RVSFGKTNPK DLLQLASTLS
     HVPQIRSILE TIESPALESL VARLDAIPEL ENLISSAIDP DAPQVITEGN IIRTGFDETL
     DQYRLVMREG TSWIADIEAK EREASGITNL KIDYNKKDGY YFHVTNSQLG NVPSHFFRKA
     TLKNSERFGT EELARIEGEM LEAREKSANL EYEIFMRIRE EVGKYIQRLQ ALAQTLATVD
     VLQSFAVVAE SQHLVRPSFT SSRSLQIKKG RHAVVEKVMG AQSYIPNSIE LDQETDIQLI
     TGPNMSGKST YMRQLAMIVI MAQMGSYVPA EVASLPIFDA IFTRIGAADD LVSGQSTFMV
     EMMEANRAIR QASERSLILF DELGRGTATY DGMALAQAII EYIHDRTKAK TLFATHYHEL
     TDLSSSLTRL ENVHVATLEK DGQVTFLHKI EAGPADKSYG IHVAKIAGLP TDLLRRADAI
     LTDLENQEKR EASLPASRTD SQKVSEQMSL FVEETENPVL TELRDLDIYN MTPLEVMAAV
     AELKKKL