ID   MUTS_STRMU              Reviewed;         849 AA.
AC   Q8DRW8;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SMU_2091c;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE014133; AAN59686.1; -; Genomic_DNA.
DR   RefSeq; NP_722380.1; NC_004350.2.
DR   RefSeq; WP_002279585.1; NC_004350.2.
DR   AlphaFoldDB; Q8DRW8; -.
DR   SMR; Q8DRW8; -.
DR   STRING; 210007.SMU_2091c; -.
DR   PRIDE; Q8DRW8; -.
DR   EnsemblBacteria; AAN59686; AAN59686; SMU_2091c.
DR   KEGG; smu:SMU_2091c; -.
DR   PATRIC; fig|210007.7.peg.1861; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q8DRW8; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..849
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115146"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   849 AA;  95341 MW;  068A984A7DBB411A CRC64;
     MTKEKLSPGM QQYLDIKKDY PDAFLLFRMG DFYELFYDDA IKAAQILEIS LTSRNKNADN
     PIPMAGVPYH SAQQYIDVLI DLGYKVAIAE QMEDPKKAVG VVKREVVQVI TPGTVVDSTK
     PDSANNFLVS LDTDGSQFGL SYMDLSTGEF YATTLADLPA VRSEVLNLKT RELVIGFELS
     ENEDQLFRKQ MNLLLSFEKT VYDDVHLLDD QLKAIELAAA GKLLQYVHNT QKRELSHLQK
     LVHYEIKDYL QMAYATKSSL DLLENARSGK KHGSLYWLLD ETKTAMGTRL LRTWIDRPLV
     SSSLISKRQD IIQTFLDHFF ERSDLSDSLK GVYDIERLAS RVSFGKANPK DLLQLGQTLS
     QVPVIKTILE SFASSSLESL INQIDTLPEL EALIRSAIDS NAPITITEGG MIREGFDETL
     DKYRTVMREG TSWIADIETK ERQKSGISTL KIDYNKKDGY YFHVTNSNLS LVPDYFFRKA
     TLKNSERFGT AELAKIEGEM LEAREESANL EYDIFMRIRS QVESYIERLQ NLAKSLATVD
     VLQSLAVVAE NNHYVRPSFN HQQEISIENG RHAVVEKVMG SQEYIPNTIN FDQKTSIQLI
     TGPNMSGKST YMRQLALTVI MAQLGSFVAA DSADLPIFDA IFTRIGAADD LISGQSTFMV
     EMMEANHAIK AATPNSLILF DELGRGTATY DGMALAQAII EYIHNKVGAK TLFATHYHEL
     TDLSTRLTSL VNVHVATLEK DGEVTFLHKI ADGPADKSYG IHVAKIAGLP KDLLNRADHI
     LVDLEKMSAA VSVNLKNETK ESQPVEEQLS LFAIDNNYEE LIKKLKQLDL TNLTPRESMN
     ALFDLKELL