ID   MUTS_STRP1              Reviewed;         851 AA.
AC   Q99XL8; Q48W52;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=SPy_2148, M5005_Spy1805;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE004092; AAK34785.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52423.1; -; Genomic_DNA.
DR   RefSeq; NP_270064.1; NC_002737.2.
DR   AlphaFoldDB; Q99XL8; -.
DR   SMR; Q99XL8; -.
DR   STRING; 1314.HKU360_01919; -.
DR   PaxDb; Q99XL8; -.
DR   EnsemblBacteria; AAK34785; AAK34785; SPy_2148.
DR   KEGG; spy:SPy_2148; -.
DR   KEGG; spz:M5005_Spy1805; -.
DR   PATRIC; fig|160490.10.peg.1860; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115149"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   851 AA;  95471 MW;  737D51CBCDFEAF0A CRC64;
     MAKTNISPGM QQYLDIKKDY PDAFLLFRMG DFYELFYEDA VKAAQLLEIG LTSRNKNAEN
     PIPMAGVPHH SAQQYIDVLI ELGYKVAVAE QMEDPKQAVG VVKREVVQVI TPGTVVDSAK
     PDSANNFLVA VDFDGCRYGL AYMDVSTGEF CVTDLADFTS VRSEIQNLKA KEVLLGFDLS
     EEEQTILVKQ MNLLLSYEET VYEDKSLIDG QLTTVELTAA GKLLQYVHKT QMRELSHLQA
     LVHYEIKDYL QMSYATKSSL DLVENARTNK KHGSLYWLLD ETKTAMGMRL LRSWIDRPLV
     SKEAILERQE IIQVFLNAFI ERTDLSNSLK GVYDIERLSS RVSFGKANPK DLLQLGHTLA
     QVPYIKAILE SFDSPCVDKL VNDIDSLPEL EYLIRTAIDP DAPATISEGS IIRNGFDERL
     DHYRKVMREG TGWIADIEAK ERQASGINNL KIDYNKKDGY YFHVTNSNLS LVPEHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESSSL EYDIFMCIRA QVETYINRLQ KLAKILATVD
     VLQSLAVVAE TNHYIRPQFN DNHVITIQEG RHAVVEKVMG VQEYIPNSIS FDQQTSIQLI
     TGPNMSGKST YMRQLALTVI MAQMGSFVAA DHVDLPLFDA IFTRIGAADD LISGQSTFMV
     EMMEANQAIK RASDNSLILF DELGRGTATY DGMALAQAII EYIHDRVGAK TIFATHYHEL
     TDLSTNLTSL VNVHVATLEK DGDVTFLHKI AEGPADKSYG IHVAKIAGLP KSLLKRADEV
     LTRLETQSRS TEIISVPSQV ESSSAVRQGQ LSLFGDEEKA HEIRQALEVI DVMNMTPLQA
     MTTLYELKKL L