ID   MUTS_STRPB              Reviewed;         851 AA.
AC   Q1J9C1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=MGAS2096_Spy1838;
OS   Streptococcus pyogenes serotype M12 (strain MGAS2096).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370553;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS2096;
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA   Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in the
RT   human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000261; ABF36890.1; -; Genomic_DNA.
DR   RefSeq; WP_002991365.1; NC_008023.1.
DR   AlphaFoldDB; Q1J9C1; -.
DR   SMR; Q1J9C1; -.
DR   KEGG; spj:MGAS2096_Spy1838; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008107"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95594 MW;  8B5ADA0FD49E53DE CRC64;
     MTKTNISPGM QQYLDIKKDY PDAFLLFRMG DFYELFYEDA VKAAQLLEIG LTSRNKNAEN
     PIPMAGVPHH SAQQYIDVLI ELGYKVAVAE QMEDPKQAVG VVKREVVQVI TPGTVVDSAK
     PDSANNFLVA VDFDGCRYGL AYMDVSTGEF CVTDLADFTS VRSEIQNLKA KEVLLGFDLS
     EEEQTILVKQ MNLLLSYEET VYEDKSLIDG QLTTVELTAA GKLLQYVHKT QMRELSHLQA
     LVHYEIKDYL QMSYATKSSL DLVENARTNK KHGSLYWLLD ETKTAMGMRL LRSWIDRPLV
     SKEAILERQE IIQVFLNAFI ERTDLSNSLK GVYDIERLSS RVSFGKANPK DLLQLGYTLA
     QVPYIKAILE SFDSPCVDKL VNDIDSLPEL EYLIRTAIDP DAPATISEGS IIRTGFDERL
     DHYRKVMREG TGWIADIEAK ERQESGINNL KIDYNKKDGY YFHVTNSNLS LVPEHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESSSL EYDIFMCIRA QVETYINRLQ KLAKTLATVD
     VLQSLAVVAE TNHYIRPQFN DNHVITIQEG RHAVVEKVMG VQEYIPNSIS FDQQTSIQLI
     TGPNMSGKST YMRQLALTVI MAQMGSFVAA DHVDLPLFDA IFTRIGAADD LISGQSTFMV
     EMMEANQAIK RASDNSLILF DELGRGTATY DGMALAQAII EYIHDRVGAK TIFATHYHEL
     TDLSTKLTSL VNVHVATLEK DGDVTFLHKI AEGPADKSYG IHVAKIAGLP KSLLKRADEV
     LTRLETQSRS TEIMSVPPQV ESSSAVRQGQ LSLFGDDEKA HEIRQALEAI DVMNMTPFQA
     MTTLYELKKL L