ID   MUTS_STRPG              Reviewed;         851 AA.
AC   A2RGX2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SpyM51780;
OS   Streptococcus pyogenes serotype M5 (strain Manfredo).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=160491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Manfredo;
RX   PubMed=17012393; DOI=10.1128/jb.01227-06;
RA   Holden M.T.G., Scott A., Cherevach I., Chillingworth T., Churcher C.,
RA   Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Moule S., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S.,
RA   Skelton J., Whitehead S., Barrell B.G., Kehoe M., Parkhill J.;
RT   "Complete genome of acute rheumatic fever-associated serotype M5
RT   Streptococcus pyogenes strain Manfredo.";
RL   J. Bacteriol. 189:1473-1477(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM295007; CAM31104.1; -; Genomic_DNA.
DR   RefSeq; WP_011185079.1; NC_009332.1.
DR   AlphaFoldDB; A2RGX2; -.
DR   SMR; A2RGX2; -.
DR   KEGG; spf:SpyM51780; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008111"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95445 MW;  2EFEE68F9A8F7700 CRC64;
     MAKTNISPGM QQYLDIKKDY PDAFLLFRMG DFYELFYDDA VKAAQLLEIG LTSRNKNAEN
     PIPMAGVPHH SAQQYIDVLI ELGYKVAVAE QMEDPKQAVG VVKREVVQVI TPGTVVDSAK
     PDSANNFLVA VDFDGCRYGL AYMDVSTGEF CVTDLADFTS VRSEIQNLKA KEVLLGFDLS
     EEEQTILVKQ MNLLLSYEET VYEDKSLIDG QLTTVELTAA GKLLQYVHKT QMRELSHLQA
     LVHYEIKDYL QMSYATKSSL DLVENARTNK KHGSLYWLLD ETKTAMGMRL LRSWIDRPLV
     SKEAILERQE IIQVFLNAFI ERTDLSNSLK GVYDIERLSS RVSFGKANPK DLLQLGHTLA
     QVPYIKAILE SFDSPCVDKL VNDIDSLPEL EYLIRTAIDP DAPATISEGS IIRTGFDERL
     DHYRKVMREG TGWIADIEAK ERQASGINNL KIDYNKKDGY YFHVTTSNLS LVPEHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESSSL EYDIFMCIRA QVETYINRLQ KLAKILATVD
     VLQSLAVVAE TNHYIRPQFN DNHVITIQEG RHAVVEKVMG VQEYIPNSIS FDQQTSIQLI
     TGPNMSGKST YMRQLALTVI MAQMGSFVAA DHVDLPLFDA IFTRIGAADD LISGQSTFMV
     EMMEANQAIK RASDNSLILF DELGRGTATY DGMALAQAII EYIHDRVGAK TIFATHYHEL
     TDLSTKLTSL VNVHVATLEK DGDVTFLHKI AEGPADKSYG IHVAKIAGLP KSLLKRADEV
     LTRLETQSRS TEIMSVPPQV ESSSAVRQGQ LSLFGDEEKA HEIRQALEAI DVMNMTPLQA
     MTTLYELKKL L