ID   MUTS_STRPZ              Reviewed;         851 AA.
AC   B5XJ75;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Spy49_1759c;
OS   Streptococcus pyogenes serotype M49 (strain NZ131).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=471876;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZ131;
RX   PubMed=18820018; DOI=10.1128/jb.00672-08;
RA   McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B.,
RA   Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.;
RT   "Genome sequence of a nephritogenic and highly transformable M49 strain of
RT   Streptococcus pyogenes.";
RL   J. Bacteriol. 190:7773-7785(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000829; ACI62009.1; -; Genomic_DNA.
DR   RefSeq; WP_012561074.1; NC_011375.1.
DR   AlphaFoldDB; B5XJ75; -.
DR   SMR; B5XJ75; -.
DR   EnsemblBacteria; ACI62009; ACI62009; Spy49_1759c.
DR   KEGG; soz:Spy49_1759c; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001039; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093650"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95530 MW;  90FB0818AD5853DA CRC64;
     MAKTNISPGM QQYLDIKKDY PDAFLLFRMG DFYELFYEDA VKAAQLLEIG LTSRNKNAEN
     PIPMAGVPHH SAQQYIDVLI ELGYKVAVAE QMEDPKQAVG VVKREVVQVI TPGTVVDSAK
     PDSANNFLVA VDFDGCRYGL AYMDVSTGEF CVTDLADFTS VRSEIQNLKA KEVLLGFDLS
     EEEQTILVKQ MNLLLSYEET VYEDKSLIDG QLTTVELTAA GKLLQYVHKT QMRELSHLQA
     LVHYEIKDYL QMSYATKSSL DLVENARTNK KHGSLYWLLD ETKTAMGMRL LRSWIDRPLV
     SKEAILERQE IIQVFLNAFI ERTDLSNSLK GVYDIERLSS RVSFGKANPK DLLQLGHTLA
     QVPYIKAILE SFDSPCVDKL VNDIDSLPEL EYLIRTAIDP DAPATISEGS IIRNGFDERL
     DHYRKVMREG TGWIADIEAK ERQESGINNL KIDYNKKDGY YFHVTNSNLS LVPEHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESSSL EYDIFMCIRA QVETYINRLQ KLAKTLATVD
     VLQSLAVVAE TNHYIRPQFN DNHVITIQEG RHAVVEKVMG VQEYIPNSIS FDQQTSIQLI
     TGPNMSGKST YMRQLALTVI MAQMGSFVAA DHVDLPLFDA IFTRIGAADD LISGQSTFMV
     EMMEANQAIK RASDNSLILF DELGRGTATY DGMALAQAII EYIHDRVGAK TIFATHYHEL
     TDLSTKLTSL VNVHVATLEK DGDVTFLHKI AEGPADKSYG IHVAKIAGLP KSLLKRADEV
     LTRLETQSRS TEIISVPSQV ESSNAVRQGQ LSLFGDEEKA HEIRQALEAI DVMNMTPLQA
     MTTLYELKKL L