ID   MUTS_STRS2              Reviewed;         847 AA.
AC   A4W4J7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SSU98_2128;
OS   Streptococcus suis (strain 98HAH33).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=391296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=98HAH33;
RX   PubMed=17375201; DOI=10.1371/journal.pone.0000315;
RA   Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X.,
RA   Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J.,
RA   Dong Y., Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F.,
RA   Yang R., Wang J., Yu J.;
RT   "A glimpse of streptococcal toxic shock syndrome from comparative genomics
RT   of S. suis 2 Chinese isolates.";
RL   PLoS ONE 2:E315-E315(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000408; ABP93286.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4W4J7; -.
DR   SMR; A4W4J7; -.
DR   PRIDE; A4W4J7; -.
DR   KEGG; ssv:SSU98_2128; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..847
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075568"
FT   BINDING         603..610
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   847 AA;  95248 MW;  90AD84FC7B696BBC CRC64;
     MMATEKISPG MQQYLDIKAQ YPDAFLLFRM GDFYELFYED AVEAAQILEL SLTSRNKNAE
     NPIPMAGVPY HAAQQYIDTL VELGHKVAIA EQMEDPKQAV GVVKREVVQV ITPGTVTDSS
     KMGADSNYLV AIDRQGVQFA LSYMDVSTGQ FFVTSLDDFT SLCGEIRNLR ARELVIGYAL
     SEEEEQVFSN QMNLLLSFED EVTEDVQLID NSLTDLEKAA AGKLLSYLHR TQMRDLSHLQ
     KVVHYEIKDY LQMDYATKSS LDLLENGRTG KKHGSLYWLL DETKTAMGMR LLRTWIDRPL
     IDLKRIENRQ AVVQVFLDYF FERSDLVEAL KGVYDIERLA SRVSFGKTMP KDLLQLSQTL
     GNIPAIKNIL QQINEPALGN LVAGLDPIPE LHALISSAID PEAQGTITDG NIIRTGFDET
     LDQYRLVMRE GAGWIAEIEA KEREASGINN LKIDYNKKDG YYFHVTNSNL GNVPDHFFRK
     ATLKNSERYG TEELAKIEGQ MLEARDKSAN LEYEIFMRIR QEVEKYIGRL QKLARTIATI
     DVLQAFAVVA EQQHLVCPRF TDQRELTIDR GRHAVVEKVM GKQTYIPNSI HLNTDTHMQL
     ITGPNMSGKS TYMRQLAVIV IMAQMGSYVP ADQAELPIFD AIFTRIGAAD DLVSGQSTFM
     VEMMEANKAV RLATDRSLIL FDELGRGTAT YDGMALAQSI IEYIHDKIGA KTLFATHYHE
     LTDLSQTLEH LENVHVSTLE KDGQVTFLHK IAQGPADKSY GIHVAKIAGM PEELLQRADR
     ILQTLENQAP TAPTHPAPSV VEEPSGQLDL FADTPSHPVL DELEKLDIYN MTPMEVMMAV
     AELKKKI