ID   MUTS_STRS7              Reviewed;         851 AA.
AC   C0MGC5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SZO_18730;
OS   Streptococcus equi subsp. zooepidemicus (strain H70).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H70;
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F.,
RA   Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M.,
RA   Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A.,
RA   Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C.,
RA   Maskell D.J., Parkhill J., Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; FM204884; CAX00811.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0MGC5; -.
DR   SMR; C0MGC5; -.
DR   EnsemblBacteria; CAX00811; CAX00811; SZO_18730.
DR   KEGG; seq:SZO_18730; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001368; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202744"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95095 MW;  EED4EC65779739AB CRC64;
     MAKANVSPGM QQYLDIKKNY PDAFLLFRMG DFYELFYEDA VKAAQILEIG LTSRNKNADN
     PIPMAGVPYH SVQQYIDVLI DLGHKVAIAE QMEDPKQAVG VVKREVVQVI TPGTAVDSSR
     PDSPNNFLVA VDFDGKAYGL SYMDVSTGEF FATDLADFAS VKSEIQNLKA REVLLGFELS
     EEEQAILVKQ MNLLLSFETT ALEDSPLIDH QLTAVELSAA GKLLHYVHQT QLRELSHLQT
     LVHYDIKDYL QMSYATKSSL DLLENARTGK KHGSLYWLLD ETKTAMGMRL LRAWIDRPLV
     TSEAILERQE IIQVFLNAFI ERTDLSDSLK GVYDIERLSS RVSFGKANPK DLLQLGHTLA
     KVPYIKAVLE AFNSPYLDKL VNQIDTLPEL EHLIRSAIDP DAPATINEGN IIRTGFDERL
     DHYRKVMREG TGWIADIETK ERQASGISNL KIDYNKKDGY YFHVTNSNLG MVPDHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESSSL EYDIFMRIRA QVETYIDRLQ QLAKALATVD
     VLQSLAVVAE KNHYVRPLFN QESRIAIDNG RHAVVEKVLG VQEYIPNSIS FGPQTSIQLI
     TGPNMSGKST YMRQLALTVI MAQIGSFVAA ESASLPLFDA IFTRIGAADD LISGQSTFMV
     EMMEANHAIK RATPHSLILF DELGRGTATY DGMALAQSII EYIHDRVGAK TMFATHYHEL
     TELSTKLTKL VNVHVATLEK DGNVTFLHKI AEGPADKSYG IHVARIAGLP EDLLARADAV
     LTKLEAQSQA RESVLSTTEV RETQQLANQQ LSLFTDDGSS SEIIKRLESV DVMNLTPIQA
     MTVLYELKKL L