ID   MUTS_STRSV              Reviewed;         849 AA.
AC   A3CR17;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SSA_2260;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000387; ABN45622.1; -; Genomic_DNA.
DR   RefSeq; WP_011837653.1; NC_009009.1.
DR   RefSeq; YP_001036172.1; NC_009009.1.
DR   AlphaFoldDB; A3CR17; -.
DR   SMR; A3CR17; -.
DR   STRING; 388919.SSA_2260; -.
DR   EnsemblBacteria; ABN45622; ABN45622; SSA_2260.
DR   KEGG; ssa:SSA_2260; -.
DR   PATRIC; fig|388919.9.peg.2143; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..849
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008112"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   849 AA;  94741 MW;  9F4F3CAE9E337C32 CRC64;
     MAVEKLSPGM QQYLDIKKDY PDAFLLFRMG DFYELFYDDA VNAAQILEIS LTSRNKNAEN
     PIPMAGVPYH SAQQYIDVLV ESGYKVAIAE QMEDPKEAKG VVKREVVQVI TPGTVVDSSK
     PDSANNFLVA LDYSDGLYGL AYMDLVTGEF QVTSLEDFAL VCGEIRNLKA REVVLGYALP
     EAEEQVLAGQ MNLLLSYVQT ALDDVQLLGE ELSPMERQAA GKLLEYVHRT QMRELSHLKK
     AQHYEIKDFL QMDYATKASL DLTENARSGK KHGSLYWLMD ETKTAMGGRM LRSWIQRPLI
     DEARISQRQN VVEVFLDHFF ERSDLTESLK GVYDIERLAS RVSFGKTNPK ELLQLAATLG
     NVPQIKAILQ GIGSPHLARL IEGLDPIPEL AGLISSAISP DAPHIITEGN IIQTGFDETL
     DQYRLVLREG TGWIAELEVK ERANSGISNL KIDYNKKDGY YFHVTNSQLA HVPSHFFRKA
     TLKNSERFGT EELARIEGEM LEAREKSANL EYEIFMRIRE EAGKYIQRLQ ALAQTLAAVD
     VLQSFAAVAE QQHLVRPVFT AERRLQIEKG RHAVVEKVMG AQSYIPNSIL LDQETDIQLI
     TGPNMSGKST YMRQLAIIVI MAQMGSYVPA QSASLPLFDA IFTRIGAADD LVSGQSTFMV
     EMMEANRAIR QASERSLILF DELGRGTATY DGMALAQAII EHIHHYTGAK TLFATHYHEL
     TALEESLEHL ENVHVATLEK DGQVTFLHKI EPGPADKSYG IHVAKIAGLP EKLLERADSI
     LSHLESQDTG LGSELPTASR PKQSQVAEQM SLFAEGTENP VLTELRDLDI YNMTPLEVMA
     AVAELKKKL