ID   MUTS_STRT1              Reviewed;         852 AA.
AC   Q5M1Z0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=str0050;
OS   Streptococcus thermophilus (strain CNRZ 1066).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=299768;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNRZ 1066;
RX   PubMed=15543133; DOI=10.1038/nbt1034;
RA   Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA   Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA   Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA   Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT   "Complete sequence and comparative genome analysis of the dairy bacterium
RT   Streptococcus thermophilus.";
RL   Nat. Biotechnol. 22:1554-1558(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000024; AAV61667.1; -; Genomic_DNA.
DR   RefSeq; WP_011226740.1; NC_006449.1.
DR   AlphaFoldDB; Q5M1Z0; -.
DR   SMR; Q5M1Z0; -.
DR   KEGG; stc:str0050; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..852
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224412"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   852 AA;  95438 MW;  0BACF4819501A20A CRC64;
     MAKEKISPGM QQYLDIKKNY PDAFLLFRMG DFYELFYDDA VKAAQILEIS LTSRNKNADN
     PIPMAGVPYH SAQAYIDVLV EMGYKVAIAE QMEDPKQAVG VVKREVVQVI TPGTVVDSSK
     PDSANNFLVA IDKVGSRFGL SYMDVSTGEF FATELDDFSS VCSEIQNLKA REVVVGYDLL
     ETDEQVLVNQ LNLLLSKETE GYDDVHLIGN SLTDLESSVA SKLLQYVHRT QMRELSHLQK
     AQHYEIKDYL QMSYATKSSL DLLENARTGK KHGSLFWLLD KTKTAMGMRL LRTWIDRPLV
     NQASIIERQN IIQVFLDNFF ERSDLAESLK GVYDIERLAS RVSFGKANPK DLIQLGHTLA
     QVPVIKAILE SFNDDALSGL LQELDALPEL ESLIRSAIDP DAPATITEGG IIRDGFDETL
     DKYRKVMSEG TSWIADIEAK EREASGITTL KIDYNRKDGY YFHVTNSNLS LVPDHFFRKA
     TLKNSERFGT AELAKIEGEM LEAREKSSTL EYDIFMRVRE QVERYIDRLQ SLAKAIATVD
     VLQSLAVTAE TNHYVRPVFN DEHRIAIDRG RHAVVEKVMG VQEYIPNTIT FDSQTNIQLI
     TGPNMSGKST YMRQLALSVV MAQMGAYVPA DSVDLPVFDA IYTRIGAADD LISGQSTFMV
     EMMEANQAIK RATPNSLIIF DELGRGTATY DGMALAQSII EFIHDKVGAK TMFATHYHEL
     TALSNSLTHL VNVHVATLEK DGEVTFLHKI VDGPADKSYG IHVAKIAGLP TDLLNRADTI
     LTQLEGETVV IQPQEKVLSQ EKPAIETHVN EQISLFDDFT ENPVLQELRD LDIYNMTPMQ
     VMMAVADLKQ KL