ID   MUTS_STRU0              Reviewed;         847 AA.
AC   B9DW73;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SUB1786;
OS   Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=218495;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-854 / 0140J;
RX   PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA   Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA   Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA   Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA   Parkhill J.;
RT   "Evidence for niche adaptation in the genome of the bovine pathogen
RT   Streptococcus uberis.";
RL   BMC Genomics 10:54-54(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM946015; CAR43783.1; -; Genomic_DNA.
DR   RefSeq; WP_015912076.1; NC_012004.1.
DR   AlphaFoldDB; B9DW73; -.
DR   SMR; B9DW73; -.
DR   STRING; 218495.SUB1786; -.
DR   PRIDE; B9DW73; -.
DR   EnsemblBacteria; CAR43783; CAR43783; SUB1786.
DR   KEGG; sub:SUB1786; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000449; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..847
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192208"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   847 AA;  95398 MW;  8E8626EEA8BADAE9 CRC64;
     MADSKISPGM QQYLDIKAQY PDAFLLFRMG DFYELFYDDA VKAAQLLEIG LTSRNKNAEN
     PIPMAGVPHH SAQQYIDILI ELGYKVAIAE QMEDPKKAVG VVKREVVQVI TPGTVVDSAK
     PNSSNNFLIA IDFDGSHYGL SYMDLVTGEF FATTLSDFMS VCGEILNLKA KEVVIGFEIT
     AEQEEQLQKQ FRLLLSYEQE IYTDDTLINP NLSQVEKNVA GKLLQYVHQT QMRELSHLQE
     LIHYDIKDYL QMSYATKSSL DLIENARTKK KHGSLYWLLD ETKTAMGMRL LKTWIDRPLI
     SKQAISERQN IVETFLESFI ERSDLADSLK GVYDIERLSS RVSFGKVNPK DLLQLGHTLS
     QVPYIKAVLE AINSPHLSKV IATIDPIPEL ESLIHSAIDP DAPATISEGS IIKTGFDQRL
     DHYRKVMKEG TGWIADIEMK ERQASGINNL KIDYNKKDGY YFHVTNSNLS LVPDHFFRKA
     TLKNSERYGT AELAKIEGQM LEAREESAQL EYDIFMRIRE KVETYIDRLQ TLAKAIATVD
     VLQGLAYVAE KNHYVRPEFA SQKVITIQNG RHAVVEKVMG VQEYIPNTIQ FNQNTSIQLI
     TGPNMSGKST YMRQLALTVI MAQMGSYVAA DYAKLPIFDA IFTRIGAADD LISGQSTFMV
     EMMEANQAIQ RASHDSLIIF DELGRGTATY DGMALAQSII EHIHNRIGAI TLFATHYHEL
     TSLSEELGHL KNVHVAILER DGEVTFLHKI AEGPADKSYG IHVAKIAGLP GSLLSRADNI
     LKQLESHSKD FIIKDNSQQS EENEPLNLLT EETSSQDIIN RLKEVDVMNM TPMEAMTVLF
     DLKKKIK