ID   MUTS_SYMTH              Reviewed;         875 AA.
AC   Q67NK1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=STH1757;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP006840; BAD40742.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q67NK1; -.
DR   SMR; Q67NK1; -.
DR   STRING; 292459.STH1757; -.
DR   EnsemblBacteria; BAD40742; BAD40742; STH1757.
DR   KEGG; sth:STH1757; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..875
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224413"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   875 AA;  96685 MW;  F1B62AEB01499E98 CRC64;
     MDPAKATPMF AQYLQIKEQY PDCILFYRLG DFYETFMDDA ELVARELELV LTGRDAGKDM
     GRVPMAGIPY HAAEAYIARL IEKGYKVAIC DQLEDPKKAK GLVKRDVTRV VTPGTLVEPR
     LLPEKANNFL AAIAWSRTGF GLAVVDLSTG EFAAAQMNGA DSLRLLLEEI GRLEPREVIL
     EPGLAAEPSV TGPLKASGIA VSVFEGRHFN HANAYRKLTE HFGTANLSGF GCEDLELATS
     AAGAALAYLE EMHKASLGHV SGLAVYYPGD YMVLDPATRR NLELTRSLRD GGRRGTLLWV
     MDRTVTAMGA RLLKSWLERP LLDLRQIHAR HEAVGELVHR PVLRADLRAL LQEVHDLERL
     AGRVAVGSAN ARDLVALKQS LVALPSIRVA LEDVRAERLV ELRDQLDMLD DVRDLIEHAI
     ADEPPVALTE GGILKDGFHP EVDELRRIAR DGKAWIAQVE ARERERTGIK SLKIGYNKVF
     GYYLAVTKPN LPLVPPDYIR KQTLANEERF ITPELKELEE KVLHAAERVM DLEYELFVEI
     RQRVAAEVTR IQRSARAVAE LDALASFAEV ASLYGYCRPL VDGSTVLELK GSRHPVLERV
     MEEGAFVPND LLVDTGENRV LLITGPNMGG KSTVMRQAAL AVILAQAGSF VPAESAHIGL
     VDRVFTRVGA SDDLATGRST FMVEMTEVAN ILHSATERSL VVLDEVGRGT ATFDGLSIAW
     AITEHIHQAI GCRTLFATHY HELCELEGIL PGVKNYSVAV MEKGEDIIFL RKLVRGGADR
     SYGIQVGRLA GLPASVVERA REILATLEEQ EGERKSRREA AAQRLRRQPA VQLTFFEPKK
     DPVVEELLGL NVMALTPIEA LNTLYQLQAK AKENR