ID   MUTS_SYNAS              Reviewed;         880 AA.
AC   Q2LUL3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SYNAS_18980;
GN   ORFNames=SYN_01405;
OS   Syntrophus aciditrophicus (strain SB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophales; Syntrophaceae;
OC   Syntrophus.
OX   NCBI_TaxID=56780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB;
RX   PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA   McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA   Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA   Campbell J.W., Gunsalus R.P.;
RT   "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT   of microbial growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000252; ABC77777.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2LUL3; -.
DR   SMR; Q2LUL3; -.
DR   STRING; 56780.SYN_01405; -.
DR   PRIDE; Q2LUL3; -.
DR   EnsemblBacteria; ABC77777; ABC77777; SYN_01405.
DR   KEGG; sat:SYN_01405; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_7; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001933; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..880
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335237"
FT   BINDING         628..635
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   880 AA;  99704 MW;  3187ABEF5FBF0096 CRC64;
     MGMKESMEIS SLTPAMKQYA EVKALHKDCI VLFRMGDFYE IFFEDAVTAS KILDITLTSR
     NKGKEDSIPL CGFPYHASST YIPKLIEKGF KVAVCEQIED PKLAKGVVRR EVVRIVTPGL
     VVDTANLHAK ENNFLAAVFP LEHHIGLAFL DISTGEFRVS DFQDIRFFET ELAALDFREI
     MVPQGSGKQG FLKAFAGREN SCRLDEFPDE YFDRESALGR LQDYIRKEDL EDLGLKDCPA
     VIGAAGAVLR YVEETQKSRL THINRLQWYS AAEYLVLDET AKRNLELFKT IQDNRTAGSL
     FSVLDETVTA MGGRRLRWWL NYPLVDPEKI KARLAAVAEI RENHLFRENL RKVLSEVYDM
     ERLAGRIALG VANGRDLIAL KQSLKNLPVL KNLLADSNSF MLDRIQDGID ELPDLYDLIE
     KAICDSPPVT LREGGIIKEG YDEERDRLFF MTRDGRRWIA ALEEKERKRT GISSLKVGFN
     NVFGYYIEIS KANSALAPED YVRKQTLVNA ERYINQELKE YEATVLNAET RCREREYDLF
     MQVRECAAAE ITRMQATATL LADLDALASL AEVAEKYNYC CPVVDLEDRI EIDVGRHPVV
     ERMSLRDGFV PNDVVLDTDE NRFLVITGPN MAGKSTYIRQ VALIVLMAQM GSFVPSSRAR
     IGVVDRIFTR IGAADSLIRG QSTFMVEMNE VAQILCHATG RSLVILDEVG RGTSTFDGLS
     IAWAVAEYLH DKNWIGARTL FATHYHQLTE LAVAGTGYRN YNIAVKEWGD RIIFLRKIVP
     GGTNRSYGIQ VARIAGVPEE VIVRAREILD NLEKGEMDEV GMPRIARSRK RKPRNPGQLN
     LFMSERERVI EELAALNISR VEPHDALNMM LNWQERLKEG