ID   MUTS_SYNC1              Reviewed;         870 AA.
AC   Q3A4F1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pcar_1510;
OS   Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)
OS   (Pelobacter carbinolicus).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Syntrophotaleaceae; Syntrophotalea.
OX   NCBI_TaxID=338963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2380 / NBRC 103641 / GraBd1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Pelobacter carbinolicus DSM 2380.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000142; ABA88756.1; -; Genomic_DNA.
DR   RefSeq; WP_011341239.1; NC_007498.2.
DR   AlphaFoldDB; Q3A4F1; -.
DR   SMR; Q3A4F1; -.
DR   STRING; 338963.Pcar_1510; -.
DR   EnsemblBacteria; ABA88756; ABA88756; Pcar_1510.
DR   KEGG; pca:Pcar_1510; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002534; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224388"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  96865 MW;  E94F10B647435744 CRC64;
     MTKLTPMMRQ YLDIKAQYPD AILFFRLGDF YEMFMEDAVT ASRILDITLT SRNKGAAEEV
     PLCGIPYHSC QPYVARLVEA GHKVAICEQV EDPKTVKGIV KREVVRVVTP GLVVDADTLT
     PKENNFLAAI AVSAQERYGI AVLDITTGEF RVTEVEGREA ACSEVVSLQP REILVSEDQQ
     QFCEQLLQGA SGSWLINPLP DWVCDLEACG QRLQSFFNCG SLESFGCARL PEAVRAAGGV
     VYYVEQTQKG VAGHIRPLVT YHSRDYMVLD NSTRRNLELT ATLQDGGRKG SLLGVLDRTV
     TAMGGRKIRQ WIHHPLVDLK AIRDRHLSVQ ELVGQSLVRG DLRADLDGVY DLERLNSKIA
     MGHANAKDLV ALRKSFEKLP RILQHLDELS APLAAGIGSR IDPLTDMAEL IGRAIVEDPP
     FVLREGGLMC DGYHLELDEL RDIRRNGKEW IAKLEADERE RTGIGSLKVR FNKVFGYYIE
     VTRTHLGRVP EDYQRKQTLA NAERFFTPQL KEYEEKVLGA EDRLFDLEFE LFQDLRERVA
     EQGERVQRTA EALAELDVLL SLADVAHSCD YVCPTMDDSD RLVIRDGRHP VIEAMNLGEH
     FVPNDVEMDC RENQIMVITG PNMAGKSTYM RQVALITLMA HMGSLVPAAS AHIGLVDRIF
     TRVGASDNLA QGQSTFMVEM TEAAHILNHA TSRSLIVLDE IGRGTSTFDG ISIAWAVAEY
     LHDNGHVAAK TLFATHYHEL TDLILTCERV KNLNIAVREW NEQIIFLRKI VKGPASHSYG
     IQVARLAGLP VAVIDRAKEI LVNLESGELA EEGQPRLAQR AGGGQHRPNP QMSLFDAAAD
     PVREKLAALD ISTISPLEGL NFLHELQKLV