ID   MUTS_SYNE7              Reviewed;         882 AA.
AC   Q31KZ2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Synpcc7942_2247;
OS   Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS   R2).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7942 / FACHB-805;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000100; ABB58277.1; -; Genomic_DNA.
DR   RefSeq; WP_011378371.1; NC_007604.1.
DR   AlphaFoldDB; Q31KZ2; -.
DR   SMR; Q31KZ2; -.
DR   STRING; 1140.Synpcc7942_2247; -.
DR   PRIDE; Q31KZ2; -.
DR   EnsemblBacteria; ABB58277; ABB58277; Synpcc7942_2247.
DR   KEGG; syf:Synpcc7942_2247; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; SYNEL:SYNPCC7942_2247-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008114"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  98082 MW;  2B744909C6722811 CRC64;
     MTTSELPEHL AKHEVRYADH RQVERDRLTP MMQHYAEVKD QHLQQILLYR MGDFFECFFQ
     DAIVVARELE LVLTSKEAGK EVGRVPMAGI PYHALDRYAS QLVEKGYAIA ICDQVETAAQ
     AQGPLVRREI TRIITPGTIL EEGMLQARRN NFLAAVVIAG EHWGLAYADS STGDYWTSQS
     TGLEGLTQEL YRLQPSEVLF PSAAPDLAGL LRPGQSKPQQ IPDCLPDSFC YALRSPMPFE
     LHEARQRLLE HFQLRSLEGC GCEQLPLAIR AAGGLLDYLG ETQRESLAPL QKPRTYSLSE
     FLILDQQTRR NLEITQTQRD GSFHGSLLWA LDRTMTSMGG RLLRRWLLQP LLNPEAIRNR
     QAAIQELCQD GRLRQDLRSL LQKIYDLERL SGRAGAGTAN ARDLLALAES LLRLPELAQL
     LSRAQSPLLA QLQQVPPELE QLGDRLQQHL VESPPLQLTE GGLIRSGVAI ALDELRQQVE
     SDRQWIASLE ASERTATGIN SLKVGYSKTF GYFISLSRSK ADQVPDHYIR RQTLTNEERF
     ITPDLKERES RILNAQTDLN QLEYDLFVGL RSEVSHHVET IRAIATAVAA ADVLAALAEV
     AVYQNYCCPE IRDDRQLAIQ DGRHPVVEQA LPSGFYVPNS CGLGSDRGPD LIVLTGPNAS
     GKSCYLRQVG LIQLLAQIGS FVPAKNAQVG ICDRIFTRVG AVDDLATGQS TFMVEMNETA
     NILNHATARS LVLLDEIGRG TATFDGLSIA WAVAEYLARE IQARTIFATH YHELNELSGL
     LKNVANFQVT VKELPDRIVF LHQVQPGGAD RSYGIEAARL AGLPSEVIDR AREVMSRIEK
     HSRIAVGLRR GNGSQRRTQA SPQQIDATIA TEQLGLFSGP SH