ID   MUTS_SYNFM              Reviewed;         889 AA.
AC   A0LG76;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sfum_0730;
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA   Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000478; ABK16428.1; -; Genomic_DNA.
DR   RefSeq; WP_011697601.1; NC_008554.1.
DR   AlphaFoldDB; A0LG76; -.
DR   SMR; A0LG76; -.
DR   STRING; 335543.Sfum_0730; -.
DR   EnsemblBacteria; ABK16428; ABK16428; Sfum_0730.
DR   KEGG; sfu:Sfum_0730; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..889
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071280"
FT   REGION          812..831
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   889 AA;  98981 MW;  2C52F3FC50F3B9FD CRC64;
     MNKITPMMQQ YLEIKEKYPD ALLLYRMGDF YEMFMDDAVT ASGLLEIALT SRDRQSEVRI
     PMCGVPYHAA EGYIARLVSA GKKVAICDQV EDPRKAKGLV RREVTRVITP GLVLDAQNLA
     AKQPNYLAAV SNSTAGERFG LAFLDVSTAE FKMVEIESRE ALLEELIRVS PRELLLSDDD
     EHPWAEELPK LYGIALTPLG ADRFDGKRAE EALVGHFRVH SLEGFGISGM DLGIRAAGAI
     LAYMQANLLG SCDHITRLLP YSRGDFMIVD EAGVRNLEIF HSQSFQGRKG SLIDILDETK
     TAMGGRKLQQ WLRYPLLDLA RINNRREAIA ELAANAPMRG ETLGLLSRIS DVERLNGRNS
     TGTSTPRDLV ALKKSLQNLP ALGAALAELT SPRLSELRAR WDDLADVADI IERTLLDPPP
     PGLAAGGVIS AGVSEELDHF VRLSRDAKGW MADYEVQQRR DTGISSLKVR YNKVFGYYIE
     ISNANLNSVP EHYFRKQTLV NAERFITEEL KTFETQVLQA EEKRLELEQQ IFADLRARIA
     REAGRIQAAA DRIADLDCVS ALAEVACRYD YCRPVMDESD AIRIRDGRHP VIEHYLKDGT
     FVPNDLDMDQ RDQQVLVITG PNMAGKSTIL RQAALIVLMG HIGSFVPASE AHIGLVDRIF
     TRVGASDDLA RGRSTFMVEM QETANILHHA TPRSLIILDE IGRGTSTYDG LSIAWAVAEH
     LHDFQEKGIK TLFATHYHEL TELARSRPRV RNFNVAIREW QQEILFFHKL VQGGASRSYG
     IQVARLAGLP EEVTGRAREI LQQLESGHAP FAAAPSGAAR RGRPAREKEP GIQMSLFQRS
     PEWLRDRILA LDLDNMTPIA ALQNLHALKE QIRGSAGEEP ASCASRGKR