ID   MUTS_SYNJA              Reviewed;         882 AA.
AC   Q2JT35;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CYA_2035;
OS   Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone
OS   A-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-3-3Ab;
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000239; ABD00175.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2JT35; -.
DR   SMR; Q2JT35; -.
DR   STRING; 321327.CYA_2035; -.
DR   EnsemblBacteria; ABD00175; ABD00175; CYA_2035.
DR   KEGG; cya:CYA_2035; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008818; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335233"
FT   REGION          833..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  98190 MW;  F07372A4ED417E70 CRC64;
     MDPALLTPMM QHYVELKRQY PHAILLYRLG DFYEMFFQDA QLVSRELELV LTGREAGAIG
     RVPMCGIPYH AFDRYAAQLV AKGYALAVCD QMEPADQAKG LVRREVTRVI TPGTVIEEEL
     LQARQNNYLA AIVRLRGSKQ TVWGLAYADI STGEFWVCQG EGQEQLEQEL ARLQPAEILL
     PTEEGLGLGL MRPGDPQAPL GLPGQYTYTL RPAEPFELAT ARENLLQTYG LRSLEGLGCE
     GLPLAIRAAG GLLHYLEETQ KNLVQPSPQG GHPLLRPPRT YQLTDYLILD TQTRRNLELT
     QTIREGAFVG SLLWVLDRSR TAMGGRTLRR WLLQPLRDPE QIRLRQDTIQ ELLESPSLRT
     RLGSLLDSLY DLERLANRVA SGTANPRELV ALGSSLGKLP QLAELVAEAQ TPLLQSLQQV
     DPALVDLGHR IEHTLLPSPP PVLTEGGLIR PGVDAELDRL RQQVEQDRHW IAQLEKTERE
     RTGIPTLKVG FNKAFGYYLS ISRAKAQQVP KEYIRKQTLT NEERFITPEL KEKEARILTA
     QTEINQREYE LFVQLRQEAG SQAAAIRQVA QTLAAVDALF GLAEVAVQQG YTRPVITADR
     RLIIEEGRHP VVEKSLPQGL FVPNSVRLGS PHGPDLIVLT GPNMSGKSTY LRQIGLIQIL
     AQMGSFVPAR RAELGLCDRV FTRIGAVDDL ATGQSTFMVE MNETANILNH AGERSLVLLD
     EIGRGTATFD GLSIAWAVAE YLATQVRART IFATHYHELN QLETLLPNVA NFQVVVKELR
     DRIIFLHQVQ PGGADRSYGI EVGRMAGLPQ PVIERAKQVL ALVEQHSRIG LGLRSQGKSR
     PSSNNPKKRF KQESNSRGIP DCDAKAGDQL SLIPTSLYPE EL