ID   MUTS_SYNJB              Reviewed;         884 AA.
AC   Q2JIA6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CYB_2731;
OS   Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium
OS   Yellowstone B-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-2-3B'a(2-13);
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000240; ABD03656.1; -; Genomic_DNA.
DR   RefSeq; WP_011434273.1; NC_007776.1.
DR   AlphaFoldDB; Q2JIA6; -.
DR   SMR; Q2JIA6; -.
DR   STRING; 321332.CYB_2731; -.
DR   KEGG; cyb:CYB_2731; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001938; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..884
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335232"
FT   REGION          843..884
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         651..658
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   884 AA;  98244 MW;  18EE88622C6B3B6A CRC64;
     MDPALLTPMM QHYVELKRQY PHAILLYRLG DFYEMFFQDA QRVSRELELV LTGREAGAIG
     RVPMCGIPYH AFDRYAAQLV AKGYALAVCD QMEPADQAKG LVRREVTRVI TPGTVLEEEL
     LQARQNNYLA AVVRLKGSKQ APCRWGLAYA DISTGEFWVC QSEGQEQLEQ ELARLQPAEV
     LLPTEEGLGL GLIRPGDPQK PLGLPNQYAY TLRPAEPFEL AVARENLMQT YGLRSLEGLG
     CEGLPLAVRA AGGLLHYLEE THSPQRCVAP KTLLQPSPQG GHPLLPPPRT YQLTDYLILD
     AQTRRNLELT QTIREGAFVG SLLWVLDHSR TAMGGRTLRR WLLQPLRDSE QIRLRQDTIQ
     ELLENPSLRA RLGSLLDSLY DLERLANRVG SGTANPRELV ALGSSLGKLP QLAELVGEAK
     TPLLQSLQQV DPALVDLGRR IEHTLLPSPP PILTEGGLIR PGVDPELDRL RQQVEQDRQW
     VAQLEKSERD RTGIPTLKVG FNKAFGYYLS ISRAKAHQVP KEYIRKQTLT NEERFITPEL
     KEKEARILTA QTDINQREYE LFVQLRQEAG SRAEAIRQVA QTLAAVDALF GLAEVAVQQG
     YTRPLLTTDR RLIIEEGRHP VVEKSLPQGL FVPNSVQLGS PHGPDLIVLT GPNMSGKSTY
     LRQIGLIQIL AQMGSFVPAR RAELGLCDRV FTRIGAVDDL ATGQSTFMVE MNETANILNH
     AGERSLVLLD EIGRGTATFD GLSIAWAVAE YLATQVRART VFATHYHELN QLETLLPNVA
     NFQVVVKELQ DRIIFLHQVQ PGGADRSYGI EVGRMAGLPQ PVIQRAEQVL ALVEKHSRIG
     LGLRNQGKSQ PAQKNCKKEP APNRSPDPAV GDQLSLIPAP LFPD