ID   MUTS_SYNP6              Reviewed;         882 AA.
AC   Q5N0X9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=syc1851_c;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008231; BAD80041.1; -; Genomic_DNA.
DR   RefSeq; WP_011244161.1; NC_006576.1.
DR   AlphaFoldDB; Q5N0X9; -.
DR   SMR; Q5N0X9; -.
DR   STRING; 269084.syc1851_c; -.
DR   EnsemblBacteria; BAD80041; BAD80041; syc1851_c.
DR   KEGG; syc:syc1851_c; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224414"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  98083 MW;  7AB6CB01EED68C5D CRC64;
     MTTSELPEHL AKHEVRYADH RQVERDRLTP MMQHYAEVKD QHLQQILLYR MGDFFECFFQ
     DAIVVARELE LVLTSKEAGK EVGRVPMAGI PYHALDRYAS QLVEKGYAIA ICDQVETAAQ
     AQGPLVRREI TRIITPGTIL EEGMLQARRN NFLAAVVIAG EHWGLAYADS STGDYWTSQS
     TGLEGLTQEL YRLQPSEVLF PSAAPDLAGL LRPGQSKPQQ IPDCLPDSFC YALRSPMPFE
     LHEARQRLLE HFQLRSLEGC GCEQLPLAIR AAGGLLDYLG ETQRESLAPL QKPRTYSLSE
     FLILDQQTRR NLEITQTQRD GSFHGSLLWA LDRTMTSMGG RLLRRWLLQP LLNPEAIRNR
     QAAIQELCQD GRLRQDLRSL LQKIYDLERL SGRAGAGTAN ARDLLALAES LLRLPELAQL
     LSRAQSPLLA QLQQVPPELE QLGDRLQQHL VESPPLQLTE GGLIRSGVAI ALDELRQQVE
     SDRQWIASLE ASERTATGIN SLKVGYSKTF GYFISLSRSK ADQVPDHYIR RQTLTNEERF
     ITPDLKERES RILNAQTDLN QLEYDLFVGL RSEVSHHVET IRAIATAVAA ADVLAALAEV
     AVYQNYCCPE IRDDRQLAIQ DGRHPVVEQA LPSGFYVPNS CGLGSDRGPD LIVLTGPNAS
     GKSCYLRQVG LIQLLAQIGS FVPAKNAQVG ICDRIFTRVG AVDDLATGQS TFMVEMDETA
     NILNHATARS LVLLDEIGRG TATFDGLSIA WAVAEYLARE IQARTIFATH YHELNELSGL
     LKNVANFQVT VKELPDRIVF LHQVQPGGAD RSYGIEAARL AGLPSEVIDR AREVMSRIEK
     HSRIAVGLRR GNGSQRRTQA SPQQIDATIA TEQLGLFSGP SH