ID   MUTS_SYNPW              Reviewed;         910 AA.
AC   A5GHU5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=SynWH7803_0084;
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=32051;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH7803;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CT971583; CAK22510.1; -; Genomic_DNA.
DR   RefSeq; WP_011932018.1; NC_009481.1.
DR   AlphaFoldDB; A5GHU5; -.
DR   SMR; A5GHU5; -.
DR   STRING; 32051.SynWH7803_0084; -.
DR   PRIDE; A5GHU5; -.
DR   EnsemblBacteria; CAK22510; CAK22510; SynWH7803_0084.
DR   KEGG; syx:SynWH7803_0084; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001566; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335235"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         726..733
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  98691 MW;  AAAB322D51C2BD91 CRC64;
     MPRSAAQSEE QTLQGSLFGA PEPAEPAKGR SSQPANPELE DLTDASLSAD AAARPRQRQQ
     RGESNDPSAD ATAEACDGDD ASSDEPAWAH HSQVDPAQLT PMLRHYVELK AEHPERVLLY
     RLGDFFECFF EDAVELSRVL ELTLTGKEGG KAIGRVPMAG IPHHAAERYC AELIRRGYSV
     ALCDQLETTP AKGALLKRGI TRVLTPGTVL EEGMLSARRN NWLAAVVVEP ATSKTPLRWG
     LASADVSTGD VRVMERTGSD GLHQQLAQLD ASELLWAGDG DSGEAARPTW CPERLRLSPM
     ARTPFSAPQA EQTLKTHYQL ASLDGLGLPE LPLALRAFGG LLQYVNDTQP LEEDARVPLD
     VPAIVHSGEA LVLDAQTRRN LELTATQRDG QLQGSLLWAI DQTLTAMGGR CLRRWLEAPL
     MNLSAIQQRQ AVVSLLVSGR PLRQALRRLL RPMGDLERLA GRAGAGHAGA RDLVAIADGL
     ERLPQLASRL QSSLEQWPNE LTALQQPEPA LAELAASIRQ TLIDAPPLSL SEGGLIHDGV
     DPLLDGLRNQ LDDQDAWLAE QERLERERSG NNNLRLQYHR TFGYFLAVSK AKASSVPEHW
     IRRQTLANEE RFITPELKER EGRIFQLRAR ACQREYELYC SLREQVGAMA APIRAAARGI
     ACLDALSGLA DTAATGGWCA PLLNDSRQLE IVAGRHPVVE QLLVETSFTP NDLNLGSGTD
     LIVLTGPNAS GKSCYLRQIG LIQLLAQIGS WVPATSARVG LADRIFTRVG AVDDLAAGQS
     TFMVEMAETA NILHHASARS LVLLDEIGRG TATFDGLSIA WAVSEHLAGD LKARTVFATH
     YHELNNLAGE RANVANFQVM VEETGADLVF LHQVQCGGAS RSYGIEAARL AGVPTPVVQR
     ARQVLDQLAA