ID   MUTS_SYNR3              Reviewed;         885 AA.
AC   A5GQ22;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=SynRCC307_0078;
OS   Synechococcus sp. (strain RCC307).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=316278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC307;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CT978603; CAK26981.1; -; Genomic_DNA.
DR   RefSeq; WP_011934496.1; NC_009482.1.
DR   AlphaFoldDB; A5GQ22; -.
DR   SMR; A5GQ22; -.
DR   STRING; 316278.SynRCC307_0078; -.
DR   EnsemblBacteria; CAK26981; CAK26981; SynRCC307_0078.
DR   KEGG; syr:SynRCC307_0078; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001115; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..885
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335234"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         691..698
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   885 AA;  97051 MW;  7EC9C87D1A380362 CRC64;
     MAPGEQQLSL VPDDTIQGSL FAPEPSEDKT EESERPKQRR SHPGRRTAPA AQHNEDSSNN
     DDEGLPRWHH HGLVDPLALT PMLRHYVELK AAHPERVLLY RLGDFFECFF EDALLTSRLL
     ELTLTGKEGG KSIGRVPMAG IPHHAAERYC SELVRRGHAV ALCDQLETTA AKGALLKRDI
     TRVLTPGTVL EEGMLAARRN NWLAAVVLDD EQRWGLAVAD VSTGELLLHE RQGTTELQQQ
     LLQLEAAELL LPGIEAAEWC PDGLGLTQQP RTPFEAASAD RALKQRFGVR NLEGLGLADH
     PLARRAAGGL IAYLDASQPG STVPLERPQL VFAGDALVLD HQTRRNLELT ATQRDGQFQG
     SLLWAIDRSH TAMGGRALRR WLEAPLLDAT AIRGRQEAIT ELVEQRPLRL SVRRLLRPMA
     DLERLAGRCG AGRASARDLV ALADGLERLP LLADLLKSSS AAPLADLQQP RPDLQQLAEL
     LRFQLVDQPP MSLSEGGLIH DGVDEDLDDL RNRLDEQENW LAGVEKRERK ASSNPNLRLQ
     FHRSFGYFLA VSRAKATAVP DHWIRRQTLS NEERFVTPEL KEREGRILQL KARSHQREYD
     LFCRLRDQVG EQATAIRDAA RAVASLDALA GLAELAATQG YCRPELTDGR CLEIEGGRHP
     VVEQLLSESA FVPNSVALGH GDKPDLVVLT GPNASGKSCY LRQCGVLQLM AQMGSWIPAE
     RAAIALADRI FTRVGAVDDL ASGQSTFMVE MAETANILQH ASERSLVLLD EIGRGTATFD
     GLSIAWAVAE HLASAPPHGL GARSIFATHY HELNALAGSH SNVANFQVVV EEQDAELVFL
     HKVMPGGADR SYGIEAARLA GVPPSVVQRA RQMLERIEGG QPLAC