ID   MUTS_SYNS3              Reviewed;         911 AA.
AC   Q0IE05;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=sync_0079;
OS   Synechococcus sp. (strain CC9311).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=64471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9311;
RX   PubMed=16938853; DOI=10.1073/pnas.0602963103;
RA   Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H.,
RA   Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S.,
RA   Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R.,
RA   Paulsen I.T.;
RT   "Genome sequence of Synechococcus CC9311: insights into adaptation to a
RT   coastal environment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000435; ABI47685.1; -; Genomic_DNA.
DR   RefSeq; WP_011618068.1; NC_008319.1.
DR   AlphaFoldDB; Q0IE05; -.
DR   SMR; Q0IE05; -.
DR   STRING; 64471.sync_0079; -.
DR   EnsemblBacteria; ABI47685; ABI47685; sync_0079.
DR   KEGG; syg:sync_0079; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001961; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..911
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335229"
FT   REGION          1..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         727..734
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   911 AA;  99572 MW;  8A9182F4BE9EFB24 CRC64;
     MALQGNLFGD AEPASSAPSK GQKRQDEPDQ LDDHELTQDA KQRPRQRQGQ QEHSEPSASS
     QSEEAHSEAS TPAGKDQDNS DDDLPPWSHH SQVTPEQLTP MLRHYVELKA AHPERILLYR
     LGDFFECFFE DAIHLSRLLE LTLTGKEAGK QIGRVPMAGI PHHAAERYCS ELIRRGLSVA
     LCDQLEAAPA SGSAKGTLLR RDITRVLTPG TVLEEGLLSA RRNNWLAAVV VEPAQGRQPF
     RWGLACADVS TGEFLVREQD NSAALHQELA RLDPAELIHH NQNSVAPSWC PERLQRCDIG
     NTPFSQPEAE ALLLERFRLQ TLDGLGLQNV PLAMRAAGGL IAYLGETCPL DDNGITPPPL
     ERPITCFPGD ALVLDAQTRR NLELIATQRD NQFQGSLLWA IDRTLTAMGA RCLRRWIEAP
     LMDPSIIRSR QASVSQLVSK RPLRQALRRL LRPMGDLERL AGRAGAGHAG ARDLVAIADG
     LERLPQLANL ITSQLDGGPS WLSDVLEPDP ALAVIGASIR HQLMDNPPLS LSEGGLIHDG
     VDPLLDGLRN QLDDQESWLA EQEQLERQSS NNSNLKLQYH RTFGYFLSVS RARSGAVPDH
     WIRRQTLANE ERFITPDLKA REGQIFQMRA RAAQREYELF CELRGQIGEH AEAIRRSARA
     IAGLDALTSL AEAAATGGWC APEITADRSM VIEQGRHPVV EQLLVEDAFT PNDSNLGTGI
     DLVVLTGPNA SGKSCYLRQI GLIQLLAQIG SWVPAQAARI GIADRIFTRV GAVDDLAAGQ
     STFMVEMAET ANILHHASER SLVLLDEIGR GTATFDGLSI AWAVSEHLAG DLQARTVFAT
     HYHELNALAG ERSNVANCQV LVEETGSDLV FLHRVAAGGA SRSYGIEAAR LAGVPASVVQ
     RARQVLDQLA T