ID   MUTS_SYNS9              Reviewed;         905 AA.
AC   Q3B0S2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Syncc9902_0081;
OS   Synechococcus sp. (strain CC9902).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=316279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9902;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Synechococcus sp. CC9902.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000097; ABB25056.1; -; Genomic_DNA.
DR   RefSeq; WP_011358923.1; NC_007513.1.
DR   AlphaFoldDB; Q3B0S2; -.
DR   SMR; Q3B0S2; -.
DR   STRING; 316279.Syncc9902_0081; -.
DR   EnsemblBacteria; ABB25056; ABB25056; Syncc9902_0081.
DR   KEGG; sye:Syncc9902_0081; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002712; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..905
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335231"
FT   REGION          1..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         721..728
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   905 AA;  98909 MW;  66BC6E1EAB9411CC CRC64;
     MELSLQGSLF GAPEPTVNAP NTRPSTGDLP NPFNSDHNLS DADLSKDALA RPRRRNETSG
     STPTAGVDPD DRADETRDDT TSTDEPAWGH HSQLKPEQLT PVLRHYVELK MAHPERVLLY
     RLGDFFECFF EDAITLSREL ELTLTGKDAG KAIGRVPMAG IPHHAAERHC SDLIRLGYSV
     ALCDQLETTP TKGALLKRDI TRVLTPGTVL EEGMLTARRN NWLAAVVVEP ATQHQPFRWG
     LAQADVSTGD VQVLQREGSD GLHQHLARLQ ASELLWSGDD PAPAWCPDRV GLTPMSSTPF
     SRPEAEAVLL EHYNLASLDG IGLPEVPLAL QAIGGLLQYV GDTQPLEDNA RVPLDVPAIV
     HNGDSLVLDA QTRRNLELTA TQRDGLLQGS LLWAIDRTLT AMGGRCLRRW IEAPLMDRSA
     IQQRQTVVSR LVEKRPLRQT LRRLLRPMGD LERLAGRAGA GHAGARDLVA IADGLERLPQ
     LAAQLNGQLT DGPAWLQALF DPQPQLQELA TTVSNTLKEA PPLSLSEGGF IHDGVDPLLD
     GLRNQLDDQD AWLAQQERQE RQGSGISTLR LQHHRTFGYF LAVSKAKTSS VPDHWIRRQT
     LANEERFITP ELKEREGHIF QLRARACQRE YELFVQLREQ VGLMATSIRE AARAVAGLDA
     LTGLADVAAT SNFCAPELTN NRELTLSAAR HPVVEQLLVE TPFTPNDVAL GNGRDLVVLT
     GPNASGKSCY LRQIGLIQLL AQVGSWVPAK EAKIGIADRI FTRVGAVDDL AAGQSTFMVE
     MAETANILHH ATSRSLVLLD EIGRGTATFD GLSIAWAVSE HLAGDLKART VFATHYHELN
     ALAGERDNVA NFQVMVEETG DNLLFLHQVR PGGASRSYGI EAARLAGVPM AVVQRAQQVL
     DQLGD