ID   MUTS_SYNSC              Reviewed;         903 AA.
AC   Q3ANH5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Syncc9605_0078;
OS   Synechococcus sp. (strain CC9605).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=110662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9605;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Synechococcus sp. CC9605.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000110; ABB33857.1; -; Genomic_DNA.
DR   RefSeq; WP_011363117.1; NC_007516.1.
DR   AlphaFoldDB; Q3ANH5; -.
DR   SMR; Q3ANH5; -.
DR   STRING; 110662.Syncc9605_0078; -.
DR   PRIDE; Q3ANH5; -.
DR   EnsemblBacteria; ABB33857; ABB33857; Syncc9605_0078.
DR   KEGG; syd:Syncc9605_0078; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..903
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335230"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         719..726
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   903 AA;  98353 MW;  BD50C175311E2EFD CRC64;
     MPRSASQPPD DALQGNLFGA PEPAAPSATA TASEPETASH DLSDDELGAD AAARPRTRQA
     TASEGSSEAP AANDSEPSRD EPAWGHHSQL DPLQLTPMLR HYVELKAAHP ERVLLYRLGD
     FFECFFEDAI ELSRVLELTL TGKEGGKAIG RVPMAGIPHH AAERYCAELI KQGYSVALCD
     QLETTPTKGA LLKRDITRVL TPGTVLEEGM LSARRNNWLA AVVVEPAQGK QPLRWGLASA
     DVSTGEVQVM QREDSSALHQ QLAQQEASEL LWAAALDTER PAWCPERLRL TPMASTPFSP
     VEAERTLQQH YGLSSLDGLG LPEHPLALQA LGGLLGYLQD TQPLEEDSRI PLEVPAIVHR
     GDALVLDAQT RRNLELTATQ RDNQLQGSLL WAIDRTLTAM GGRCLRRWLE APLMDRQAIQ
     QRQDLVSSLV GERSLRLAIR QLLRPMGDLE RLAGRAGAGH AGARDLVAIA DGLERLPQLT
     ARLKSAISTG PEWLQQLLSP DPALAELART IRHKLVEAPP LSLSEGDLIH DGVDPLLDGL
     RNQLDDQDAW LSHQEQQERQ RCGISTLKLQ HHRTFGYFLA VSKAKATAVP EHWIRRQTLA
     NEERFITPDL KEREGRIFQL RARACQREYE LFCQLREQVG AMAAPIRQAA RAVAALDALT
     GLGDVAASGG YCAPTITDGR GLQLEDSRHP VVEQRLVETA FTPNDVQLGE GTDLVVLTGP
     NASGKSCYLR QIGLIQLMAQ IGSWVPARSA TVGIADRIFT RVGAVDDLAA GQSTFMVEMA
     ETANILHHAS DRSLVLLDEI GRGTATFDGL SIAWAVSEHL AGDLGSRTVF ATHYHELNNL
     AAERDNVANF QVLVEETGED LVFLHQVQAG GASRSYGIEA ARLAGVPKPV VQRARQVLDQ
     LTA