ID   MUTS_SYNWW              Reviewed;         859 AA.
AC   Q0AYB5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Swol_0974;
OS   Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Syntrophomonadaceae;
OC   Syntrophomonas.
OX   NCBI_TaxID=335541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2245B / Goettingen;
RX   PubMed=21966920; DOI=10.1111/j.1462-2920.2010.02237.x;
RA   Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L.,
RA   McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.;
RT   "The genome of Syntrophomonas wolfei: new insights into syntrophic
RT   metabolism and biohydrogen production.";
RL   Environ. Microbiol. 12:2289-2301(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000448; ABI68289.1; -; Genomic_DNA.
DR   RefSeq; WP_011640394.1; NC_008346.1.
DR   AlphaFoldDB; Q0AYB5; -.
DR   SMR; Q0AYB5; -.
DR   STRING; 335541.Swol_0974; -.
DR   PRIDE; Q0AYB5; -.
DR   EnsemblBacteria; ABI68289; ABI68289; Swol_0974.
DR   KEGG; swo:Swol_0974; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001968; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335236"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  96754 MW;  06D8B94CDB1E697A CRC64;
     MADYTPMMQQ YLQIKEEQQD AILFFRLGDF YEMFFEDARI ASRELEIVLT ARDGGAGSKI
     PMCGVPYHSV DNYLARLINR GYKVAICEQV EDPREAKGIV KREVTRIVTP GTIIEEQLLD
     QAKNNFLAAV EEEPLCTGIA YIDISTGEFW LSEIAGENAR SRVESEILRI SPAECLLAGS
     GSLTGSWEEE WLRQQNITLT VWDELPLSLE RAESLLLRQL QVASLESFGL KSYSAGIKAA
     ARIIAFLEET QKTSLQHIKS LRCYSSDNFL EMDFYSRRNL ELTATLREGK REGSLLSILD
     ESRTAMGKRL LRRWIEQPLR EAGEIEERLD AVDELKNTLS LRTELTPLLS RINDLERLGG
     KIGASVASPR DLLGLKSSLA VINDIKKALQ PCRSEILQRL AAMDALEEVF ALIDASINDE
     APLGIKEGEL IKTGYKQEID ELRELSQEGS NWLVEFENRE KQRTGIKNLK VGFNKVFGYY
     IEITKSNLSL APADYHRKQT LVNSERFISD ELKQYEEKIL GSRERLYSLE YQEFIKIREA
     LIPYLPRVME TAHAIAILDV LQGLAEVAYQ NNYIRPEIDN SGKIRIRAGR HPVVEKALRE
     ARFVPNDLQL DRDKARFAII TGPNMGGKST FMRQAALLVL MAQMGSFIPA EEARIGLVDK
     IFTRVGASDD LAAGQSTFMV EMIEVANILN NASDNSLVIL DEIGRGTSTY DGLSIAQAVS
     EYLLENSRSK VLFATHYHQL TRLAEKLPGI INLSVSVKET GNTVVFLKKV LPGKADKSYG
     LHVARLAGLP EKLIIRAEDI LQGLEKNKDS RPAPTLLQPL LFSDSHPVVD ELKQLHIDDL
     SPREALQLLY QWQKMLDDK