ID   MUTS_SYNY3              Reviewed;         878 AA.
AC   P73769;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=sll1165;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA17821.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000022; BAA17821.1; ALT_INIT; Genomic_DNA.
DR   PIR; S74860; S74860.
DR   AlphaFoldDB; P73769; -.
DR   SMR; P73769; -.
DR   IntAct; P73769; 3.
DR   STRING; 1148.1652903; -.
DR   PaxDb; P73769; -.
DR   EnsemblBacteria; BAA17821; BAA17821; BAA17821.
DR   KEGG; syn:sll1165; -.
DR   eggNOG; COG0249; Bacteria.
DR   InParanoid; P73769; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; P73769; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..878
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115155"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   878 AA;  97586 MW;  4F2B8C58CE74D558 CRC64;
     MTDTPILGTV KEPQRDYRTL DRQKLTPMFQ HYTEVKEQYQ GALLLYRVGD FFECFFQDAV
     IIARELELIL TSKEGGKEIG RVAMTGVPHH ALDRYARQLV EKGYAVAICD QVEDAAEAQA
     EKRMVERQVT KLLTPGTLTD DSMLPAKRNN FLAAIAMVED KWGLAHADIS TGEFFTCQSS
     NLDDLAVELL RLQPSEVLIP TSAPDIRNIL RPGEPSEHIP KQLPTSFCYS LRSQAPFSLV
     EAKQRLLTTF RVKSLEGMGC EGLPLAIRAA GGLLEYIEDT QKAHVVPIQP LKTYGLTDFL
     VLDHQTRRNL EINQTVRDGS FHGSLLWALD RTSTTMGSRA LRRWLLQPLL DLKGIQARQD
     TIQELYHHPA LRQDLRQLLR QIYDLERLTG RIGANTASAR DVYGLASSLV RLTDLAELAQ
     EGHSPYLKAL QTVPPELEEL GKYVLAHIVE NPPLHIREGN LIRSGVNPTL DEMRQSLEDD
     NQWLANLEVT EREKTGIANL KVGYNKAFGY YLSLPRSKSE QAPDNYIRKQ TLVNEERYIT
     PELKERETRI LTAQADLNQL EYEIFTEVRA TVAEKAQPIR DVAKAVAAID VLAGLAEVAV
     YQGYCRPIMQ MEPGLIDIEA GRHPVVEQSL GAGFFVANDT QLGHDHWHPD LVILTGPNAS
     GKSCYLRQVG LIQLMAQTGS FIPAKTATLS ICDRIFTRVG AVDDLATGQS TFMVEMNETA
     NILNHATAKS LVLLDEIGRG TATFDGLAIA WSVAEYLAGE IQARTIFATH YHELNELASL
     LENVANFQVT VKELPEEIIF LHQVTPGGAD KSYGIEAGRL AGLPSSVITR ARQVMAQIEK
     HSKIAVGLRK GNRGKVMASQ AAAEAAEDQA KQLDIFGF