ID   MUTS_TERTT              Reviewed;         864 AA.
AC   C5BMR5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=TERTU_2828;
OS   Teredinibacter turnerae (strain ATCC 39867 / T7901).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Teredinibacter.
OX   NCBI_TaxID=377629;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39867 / T7901;
RX   PubMed=19568419; DOI=10.1371/journal.pone.0006085;
RA   Yang J.C., Madupu R., Durkin A.S., Ekborg N.A., Pedamallu C.S.,
RA   Hostetler J.B., Radune D., Toms B.S., Henrissat B., Coutinho P.M.,
RA   Schwarz S., Field L., Trindade-Silva A.E., Soares C.A.G., Elshahawi S.,
RA   Hanora A., Schmidt E.W., Haygood M.G., Posfai J., Benner J., Madinger C.,
RA   Nove J., Anton B., Chaudhary K., Foster J., Holman A., Kumar S.,
RA   Lessard P.A., Luyten Y.A., Slatko B., Wood N., Wu B., Teplitski M.,
RA   Mougous J.D., Ward N., Eisen J.A., Badger J.H., Distel D.L.;
RT   "The complete genome of Teredinibacter turnerae T7901: an intracellular
RT   endosymbiont of marine wood-boring bivalves (shipworms).";
RL   PLoS ONE 4:E6085-E6085(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001614; ACR11051.1; -; Genomic_DNA.
DR   RefSeq; WP_015817163.1; NC_012997.1.
DR   AlphaFoldDB; C5BMR5; -.
DR   SMR; C5BMR5; -.
DR   STRING; 377629.TERTU_2828; -.
DR   EnsemblBacteria; ACR11051; ACR11051; TERTU_2828.
DR   KEGG; ttu:TERTU_2828; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000009080; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202745"
FT   REGION          804..833
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95774 MW;  DEFDCC04291F6A37 CRC64;
     MNQEVKQSEV NLEQHTPMMQ QYLRIKAQHP NELVFYRMGD FYELFYEDAR KAAKLLDVTL
     TARGKSNGEP IPMAGVPYHA AENYLAKLVK LGVSVAICEQ IGDPATTKGP VERKVMRVVT
     PGTVSDEALL DEHRDNWLVA ISAHESQFGI ACLDMGSGRF SVFEIEGEDA LISEIERLRP
     AEILAPDLLT LPPGVRNKAG YRGRPEWEFD IESGLRSLCA HFATKDLDGF GCRGLTVALG
     AAGCLYAYAK ETQRTELSHI ASLVVENPDN TVSLDAATRR NLELDINLNG SEENTLFSVL
     NTTATAMGGR LLRRWINTPL RDLHTLHSRQ SAIAALLENY RFEQVQQELK HIGDLERILG
     RIALRSARPR DLTRLLNSLA IYPQLQPLLK SAECETLATL ASEINEFPGL VQELDKALVE
     NPPVVIREGG VIAEGYDEEL DELRGISTNA GEFLVKLETQ ERERTGLNTL KVGYNRVHGY
     FIEISKSQAE KAPAEYIRRQ TLKNAERFIT PELKTFEDKA LSAKSRALSR EKALYEQLIE
     KLNEHLRELQ ISAVAVAELD VLNTFAERAH ALKLVKPEFR GEAGIEIEKG RHPVVEQVLT
     DPFIPNDLTL NAQQRMLIIT GPNMGGKSTY MRQTALIVLL AQVGSYVPAE ACRLGLVDRI
     FTRIGSSDDL AGGRSTFMVE MTETANILNN ATSDSLVLMD EIGRGTSTYD GLSLAWACVE
     HLAEKLKSFT LFATHYFEIT ALPAQLPTVK NVHLDATEYQ DNIVFLHNIQ AGPASKSYGL
     QVAKLAGIPG AVLRQAKDVL HKLETGKPES PAPVASRSSK PSMQADMFAE PQPSKVEKRL
     ATVIPDDLSP RQALELVYEL KKLI