MUTS_THEAQ
ID MUTS_THEAQ Reviewed; 811 AA.
AC Q56215;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=DNA mismatch repair protein MutS;
GN Name=mutS;
OS Thermus aquaticus.
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=271;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 25104 / DSM 625 / JCM 10724 / NBRC 103206 / NCIMB 11243 / YT-1;
RX PubMed=8617781; DOI=10.1074/jbc.271.9.5040;
RA Biswas I., Hsieh P.;
RT "Identification and characterization of a thermostable MutS homolog from
RT Thermus aquaticus.";
RL J. Biol. Chem. 271:5040-5048(1996).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000305}.
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DR EMBL; U33117; AAC43637.1; -; Genomic_DNA.
DR RefSeq; WP_053767724.1; NZ_LHCI01000106.1.
DR PDB; 1EWQ; X-ray; 2.20 A; A/B=1-765.
DR PDB; 1EWR; X-ray; 3.19 A; A/B=117-765.
DR PDB; 1FW6; X-ray; 2.70 A; A/B=1-768.
DR PDB; 1NNE; X-ray; 3.11 A; A/B=1-765.
DR PDBsum; 1EWQ; -.
DR PDBsum; 1EWR; -.
DR PDBsum; 1FW6; -.
DR PDBsum; 1NNE; -.
DR AlphaFoldDB; Q56215; -.
DR SMR; Q56215; -.
DR PRIDE; Q56215; -.
DR EvolutionaryTrace; Q56215; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; DNA damage; DNA repair; DNA-binding;
KW Nucleotide-binding.
FT CHAIN 1..811
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115156"
FT BINDING 583..590
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT HELIX 15..26
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 30..36
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 39..43
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 44..54
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 67..74
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 75..77
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 78..87
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 92..97
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 101..103
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 105..107
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 110..116
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 118..120
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 124..126
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 134..148
FT /evidence="ECO:0007829|PDB:1EWQ"
FT TURN 150..152
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 155..162
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 163..173
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 176..180
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 182..186
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 188..197
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 200..203
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 211..213
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 215..232
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 246..248
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 254..259
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 262..264
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 266..268
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 272..276
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 282..293
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 299..314
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 316..326
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 332..340
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 346..366
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 368..370
FT /evidence="ECO:0007829|PDB:1FW6"
FT HELIX 376..385
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 392..397
FT /evidence="ECO:0007829|PDB:1FW6"
FT HELIX 406..433
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 439..443
FT /evidence="ECO:0007829|PDB:1EWQ"
FT TURN 444..446
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 447..453
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 454..459
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 465..469
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 471..477
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 479..511
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 514..540
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 546..556
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 561..563
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 570..576
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 578..583
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 585..588
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 589..603
FT /evidence="ECO:0007829|PDB:1EWQ"
FT TURN 604..606
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 609..616
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 620..625
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 638..652
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 657..663
FT /evidence="ECO:0007829|PDB:1EWQ"
FT TURN 664..667
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 670..687
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 690..694
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 698..701
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 708..716
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 719..721
FT /evidence="ECO:0007829|PDB:1EWQ"
FT STRAND 723..731
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 738..744
FT /evidence="ECO:0007829|PDB:1EWQ"
FT HELIX 749..762
FT /evidence="ECO:0007829|PDB:1EWQ"
SQ SEQUENCE 811 AA; 90627 MW; 43A5E5296A333515 CRC64;
MEGMLKGEGP GPLPPLLQQY VELRDQYPDY LLLFQVGDFY ECFGEDAERL ARALGLVLTH
KTSKDFTTPM AGIPLRAFEA YAERLLKMGF RLAVADQVEP AEEAEGLVRR EVTQLLTPGT
LLQESLLPRE ANYLAAIATG DGWGLAFLDV STGEFKGTVL KSKSALYDEL FRHRPAEVLL
APELLENGAF LDEFRKRFPV MLSEAPFEPE GEGPLALRRA RGALLAYAQR TQGGALSLQP
FRFYDPGAFM RLPEATLRAL EVFEPLRGQD TLFSVLDETR TAPGRRLLQS WLRHPLLDRG
PLEARLDRVE GFVREGALRE GVRRLLYRLA DLERLATRLE LGRASPKDLG ALRRSLQILP
ELRALLGEEV GLPDLSPLKE ELEAALVEDP PLKVSEGGLI REGYDPDLDA LRAAHREGVA
YFLELEERER ERTGIPTLKV GYNAVFGYYL EVTRPYYERV PKEYRPVQTL KDRQRYTLPE
MKEKEREVYR LEALIRRREE EVFLEVRERA KRQAEALREA ARILAELDVY AALAEVAVRY
GYVRPRFGDR LQIRAGRHPV VERRTEFVPN DLEMAHELVL ITGPNMAGKS TFLRQTALIA
LLAQVGSFVP AEEAHLPLFD GIYTRIGASD DLAGGKSTFM VEMEEVALIL KEATENSLVL
LDEVGRGTSS LDGVAIATAV AEALHERRAY TLFATHYFEL TALGLPRLKN LHVAAREEAG
GLVFYHQVLP GPASKSYGVE VAAMAGLPKE VVARARALLQ AMAARREGAL DAVLERLLAL
DPDRLTPLEA LRLLQELKAL ALGAPLDTMK G
