ID   MUTS_THECA              Reviewed;         817 AA.
AC   Q9ZIX6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS;
OS   Thermus caldophilus.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GK24;
RA   Nashiru O., Park B.C., Ko J.H., Kim J.S., Koh S.K., Lee H.C., Kim C.H.,
RA   Lee S.Y., Lee D.-S.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AF007553; AAD01407.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZIX6; -.
DR   SMR; Q9ZIX6; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..817
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115157"
FT   BINDING         589..596
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   817 AA;  91180 MW;  61EA066FB84BA761 CRC64;
     MPAVKMGVML KGEGPGPLPP LLQQYVELRD RYPDYLLLFQ VGDFYECFGE DAERLARALG
     LVLTHKTSKD FTTPMAGIPI RAFDAYAERL LRMGFGLAVA DQVEPAEEAE GLVRREVTQL
     LTPGTLTQEA LLPREANYLA AIATGDGWGL AFLDVSTGEF KATLLKSKSA LYDELFRHRP
     AEVLLAPELR ENEAFVAQFR KRFPVMLSEA PFDPEGEAPL ALSRARGALL AYARATQGGA
     LSVRPFRLYD PGAIVRLPEA SLKALEVFEP LRGQDTLFGV LDETRTAPGR RLLQAWLRHP
     LLERGPLEAR LDRVERFVRE GALREGVRRL LFRLADLERL ATRLELSRAS PRDLAALRRR
     SLEILPELEG LLGEEVGLPD LSGLLEELRA ALVEDPPLKV SEGGVIREGY DPDLDALRRA
     HADPVAYFLD LEVREKESTG IPTLKVGYNA VFGYYLEVTR PYYEKVPQEY RPVQTLKDRQ
     RYTLPEMKER ERELYRLEAL IKRREEEVFI ALRERARKEG EALREAARIL AELDVYAALA
     EVAVRHGYTR PRFGERLRIR AGRHPVVRRR TAFVPNDLEM AHELVRVTGP NMAGKSTFLR
     QTALIALLAQ IGSFVPAEEA ELPLFDGIYT RIGASDDLAG GKSTFMVEME EVALVLKEAT
     ERSLVLLDEV GRGTSSLDGV AIATALAEAL HERRCYTLFA THYFELTALA LPRLKNLHVA
     AKEEEGGLVF YHQVLPGPAS KSYGVEVAEM AGLPKEVVER ARALLSAMAA RREGALEEVL
     ERLLALDPDR LTPLEALRFL HELKALALGL PLGSMKG