ID   MUTS_THEM4              Reviewed;         819 AA.
AC   A6LLR1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Tmel_1001;
OS   Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429).
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX   NCBI_TaxID=391009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12029 / CIP 104789 / BI429;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Thermosipho melanesiensis BI429.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000716; ABR30862.1; -; Genomic_DNA.
DR   RefSeq; WP_012057222.1; NC_009616.1.
DR   AlphaFoldDB; A6LLR1; -.
DR   SMR; A6LLR1; -.
DR   STRING; 391009.Tmel_1001; -.
DR   EnsemblBacteria; ABR30862; ABR30862; Tmel_1001.
DR   KEGG; tme:Tmel_1001; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001110; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..819
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335238"
FT   BINDING         596..603
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   819 AA;  93809 MW;  1C04ADA988176614 CRC64;
     MGNLEKLTPM MKQYMGIKEK YKDAILLFRL GDFYEAFFED AEIISKVLNI VLTKRQNAPM
     AGIPYHALDN YLKKLVESGY KVAICEQMED ASQAKGIVKR EVTRVITPGT IIEDELLSND
     NNYLMAVIFD EKYVSAFIDV STGELFLKSF DTFLEFVDFV KISSISQVIC SKELFDKLKE
     EIPHLFVEEL DEWYFQGYEE KIKETYGLFS IEHLEITELE KKVLGALFKY LEYTLMENKP
     PQKPKRLEGS KYMILDSKTV ENLSLIPGEK GKNLFDILNK TKTSMGARLL KKWILQPLKE
     KKEILERQKL VEAFYNDHLL LNEVREYLSG VYDLERILTR LGYGKVSPKD LVSLKRSLYL
     VPSIKDALRT NENLVSFAQS LNEFNEVVGI LEKALYDEPS NAPGDGNVIK GGYSVELDDY
     RNLLFHSEEK LKEFQESERE KTGIQKLRVG FNQVFGYYIE VPKGQVKNVP DYYIRKQTLV
     NSERYITQEL KEFEEKIMSA REKVELIEKS LFEELKQKLS EYIDGLRNLA QKLSELDAIS
     NLAMVARLYG YTKPKFTGGE FYVKNARHAV VERYVSDFVA NDIYMDDRRR MYIVTGPNMS
     GKSTYIRQVG LIAVMAQIGS FVPADDAEIP IFDRVFTRMG ARDDISTGKS TFLIEMSEVA
     LILEKATKKS LVLLDEVGRG TSTFDGISIA WAMSEYIYNE IGCETMFATH FTELTELSDV
     YEGIKNLTIE VRETNNGVVF LHKVVEGIAD RSYGIEVAQI AGVPDGVVER AKEILDIISQ
     KSELEKKVRV LKEGQLKKIK SKKKIPEGQL SLFEVGDIE