MUTS_THEMA
ID MUTS_THEMA Reviewed; 793 AA.
AC P74926;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=DNA mismatch repair protein MutS;
GN Name=mutS; OrderedLocusNames=TM_1719;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Wetmur J.G., Rosenfeld A., Wong D.M.;
RT "Hyperthermophilic MutS proteins: isolation, characterization and
RT enhancement of PCR specificity.";
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000305}.
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DR EMBL; U71155; AAB16999.1; -; Genomic_DNA.
DR EMBL; AE000512; AAD36785.1; -; Genomic_DNA.
DR PIR; C72219; C72219.
DR RefSeq; NP_229518.1; NC_000853.1.
DR RefSeq; WP_004082235.1; NZ_CP011107.1.
DR AlphaFoldDB; P74926; -.
DR SMR; P74926; -.
DR STRING; 243274.THEMA_05645; -.
DR EnsemblBacteria; AAD36785; AAD36785; TM_1719.
DR KEGG; tma:TM1719; -.
DR eggNOG; COG0249; Bacteria.
DR InParanoid; P74926; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..793
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115158"
FT BINDING 589..596
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 233
FT /note="A -> G (in Ref. 1; AAB16999)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="L -> W (in Ref. 1; AAB16999)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="L -> G (in Ref. 1; AAB16999)"
FT /evidence="ECO:0000305"
FT CONFLICT 506
FT /note="K -> T (in Ref. 1; AAB16999)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 793 AA; 91066 MW; 1BCB2342E4F9B1BD CRC64;
MKVTPLMEQY LRIKEQYKDS ILLFRLGDFY EAFFEDAKIV SKVLNIVLTR RQDAPMAGIP
YHALNTYLKK LVEAGYKVAI CDQMEEPSKS KKLIRREVTR VVTPGSIVED EFLSETNNYM
AVVSEEKGRY CTVFCDVSTG EVLVHESSDE QETLDLLKNY SISQIICPEH LKSSLKERFP
GVYTETISEW YFSDLEEVEK AYNLKDIHHF ELSPLALKAL AALIKYVKYT MIAEDLNLKP
PLLISQRDYM ILDSATVENL SLIPGDRGKN LFDVLNNTET PMGARLLKKW ILHPLVDRKQ
IEERLKAVER LVNDRVSLEE MRNLLSNVRD VERIVSRVEY NRSVPRDLVA LRETLEIIPK
LNEVLSTFGV FKKLAFPEGL VDLLRKAIED DPVGSPGEGK VIKRGFSSEL DEYRDLLEHA
EERLKEFEEK ERERTGIQKL RVGYNQVFGY YIEVTKANLD KIPDDYERKQ TLVNSERFIT
PELKEFETKI MAAKERIEEL EKELFKSVCE EVKKHKEVLL EISEDLAKID ALSTLAYDAI
MYNYTKPVFS EDRLEIKGGR HPVVERFTQN FVENDIYMDN EKRFVVITGP NMSGKSTFIR
QVGLISLMAQ IGSFVPAQKA ILPVFDRIFT RMGARDDLAG GRSTFLVEMN EMALILLKST
NKSLVLLDEV GRGTSTQDGV SIAWAISEEL IKRGCKVLFA THFTELTELE KHFPQVQNKT
ILVKEEGKNV IFTHKVVDGV ADRSYGIEVA KIAGIPDRVI NRAYEILERN FKNNTKKNGK
SNRFSQQIPL FPV
