ID   MUTS_THENN              Reviewed;         801 AA.
AC   B9K800;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CTN_0907;
OS   Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=309803;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E;
RA   Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J.,
RA   Kim J.J., Park K.J., Lee S.Y.;
RT   "The genome sequence of the hyperthermophilic bacterium Thermotoga
RT   neapolitana.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000916; ACM23083.1; -; Genomic_DNA.
DR   RefSeq; WP_015919400.1; NC_011978.1.
DR   AlphaFoldDB; B9K800; -.
DR   SMR; B9K800; -.
DR   STRING; 309803.CTN_0907; -.
DR   PRIDE; B9K800; -.
DR   EnsemblBacteria; ACM23083; ACM23083; CTN_0907.
DR   KEGG; tna:CTN_0907; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000445; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..801
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118700"
FT   BINDING         590..597
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   801 AA;  92081 MW;  3938C1F4A89ED737 CRC64;
     MKMTPLMEQY LKIKEQYKDS ILLFRLGDFY EAFFEDAKTV SKVLNIVLTK RQDAPMAGIP
     YHALNTYLKK LVEAGYKVAI CDQMEEPSKS KKLIRREVTR VVTPGAIVED EFLSETNNYM
     VVLVREKEKY CAVFCDVSTG EVLIHESIDE QEVLDLMKAY SVSEIVCPEG LESEVREKLP
     GVYIEVIDEW YFSEPEEEVK RIYGIEDIHH FELSSLAMKS LSALIKYIKY TMISEKLNLK
     PPVTISRKNF MILDSATVEN LSLIPGEKGK NLFDVLNHTE TPMGARLLKK WILHPLTDRQ
     QIEDRLNAVE KLKEDRLKLE QIRNLLSRVR DVERIVSRVE YNRAIPRDLV ALRETLSVVP
     ELNEELSNFD FFEKLNFPDS LFDLLCKAIE DDPAGSPGEG KVIKRGFSPE LDEYRDLLEH
     SEEKLKEFEE REREKTGIQK LKVGYNQVFG YYIEVTKANL DKVPEDYERK QTLVNSERFT
     TPELKEFETK IMAAKERIEE LEKELFRNVC EEVKKHKETL LEISEELARI DVLATLAYDA
     ILYNYTRPTF SEDRMEIIGG RHPVVERFTR DFVENDLYMD DEKRFTVITG PNMSGKSTFI
     RQVGLISLMA QIGSFVPAKK AVLPVFDRIF TRMGARDDLA GGRSTFLVEM NEMALILLKA
     TKKSLVLLDE VGRGTGTQDG ISIAWAISEE LISRGCKVLF ATHFIELTNL ENSFPQVQNK
     TILVKEEGSN VVFTHRVVDG VADRSYGADR SYGIEVARIA GIPENVIRRA FEIMEKGFKT
     KSQRKNGKVK KFSQQIPLFP A