ID   MUTS_THEP1              Reviewed;         793 AA.
AC   A5ILG0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Tpet_1015;
OS   Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 /
OS   RKU-1).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=390874;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Thermotoga petrophila RKU-1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000702; ABQ47033.1; -; Genomic_DNA.
DR   RefSeq; WP_011943569.1; NC_009486.1.
DR   AlphaFoldDB; A5ILG0; -.
DR   SMR; A5ILG0; -.
DR   STRING; 390874.Tpet_1015; -.
DR   PRIDE; A5ILG0; -.
DR   EnsemblBacteria; ABQ47033; ABQ47033; Tpet_1015.
DR   KEGG; tpt:Tpet_1015; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006558; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..793
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008115"
FT   BINDING         589..596
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   793 AA;  91222 MW;  0E86121DBF0774AD CRC64;
     MKVTPLMEQY LRIKEQYKDS ILLFRLGDFY EAFFEDAKIV SKVLNIVLTR RQDAPMAGIP
     YHALNSYLKK LVEAGYKVAI CDQMEEPSKS KKLIRREVTR VVTPGSILED EFLSETNNYM
     AVVSEEKGQY CTIFCDVSTG EVLVHESSDE QETMDLLKNY SISQIVCPDH LKPSLKERFP
     GVYTESISEW YFSDLEEVEK AYNLKDIHHF ELSSLALKTL AALIKYVKYT MITEELNLKP
     PLLISQRDYM ILDSATVENL SLIPGDRGKN LFDVLNNTET PMGARLLKKW ILHPLVDRKQ
     IEERLETVEK LVSDRMNLEE LRDLLSNVRD VERIVSRVEY NRSVPRDLVA LRETLEIIPK
     LNEILSTFGV FKNLAFPERL LDLLQRAVED DPAGSPGEGK VIKRGFSPEL DEYRDLLEHA
     EERLKEFEEK ERKRTGIQKL KVGYNQVFGY YIEVTKANLD KIPDDYERKQ TLVNSERFIT
     PELKEFETKI MAAKERIEEL EKELFKNVCE EVKKHKEILL KISEELAKID VLSTLAYDAI
     LYSYTKPIFS EGRLEIKGGR HPIVERFTQN FVENDIYMDN ERRFVVITGP NMSGKSTFIR
     QVGLISLMAQ IGSFVPAQKA ILPVFDRIFT RMGARDDLAG GRSTFLVEMN EMALILLKST
     EKSLVLLDEV GRGTSTQDGV SIAWAISEEL IKRGCKVLFA THFTELTELE KHFPQVQNKT
     ILVKEEGKNV IFTHKVVDGV ADRSYGIEVA KIAGIPDRVI NRAYEILERN FKNNTKKNGK
     SNRFSQQIPL FPV