ID   MUTS_THESQ              Reviewed;         793 AA.
AC   B1LAW3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=TRQ2_1115;
OS   Thermotoga sp. (strain RQ2).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga;
OC   unclassified Thermotoga.
OX   NCBI_TaxID=126740;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RQ2;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA   Richardson P.;
RT   "Complete sequence of Thermotoga sp. RQ2.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000969; ACB09461.1; -; Genomic_DNA.
DR   RefSeq; WP_012310951.1; NC_010483.1.
DR   AlphaFoldDB; B1LAW3; -.
DR   SMR; B1LAW3; -.
DR   PRIDE; B1LAW3; -.
DR   EnsemblBacteria; ACB09461; ACB09461; TRQ2_1115.
DR   KEGG; trq:TRQ2_1115; -.
DR   HOGENOM; CLU_002472_3_0_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001687; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..793
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093651"
FT   BINDING         589..596
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   793 AA;  91371 MW;  820A29CF56D2740D CRC64;
     MKVTPLMEQY LRIKEQYKDS ILLFRLGDFY EAFFEDAKIV SKVLNIVLTR RQDAPMAGIP
     YHALNTYLKK LVEAGYKVAI CDQMEEPSKS KKLIRREVTR VVTPGSIVED EFLSETNNYM
     AVVSEEKGRY CTVFCDVSTG EVLVHESSDE QETLDLLKNY SISQIVCSEH LKSSLRERFP
     GVYTESISEW YFSDLEEVEK AYNLKDIHHF ELSPLALKTL AALIKYVKYT MITEDLNLKP
     PLLISQRDYM ILDSATVENL SLIPGDRGKN LFDVLNNTET PMGARLLKKW ILHPLVDRKQ
     IEERLEAVER LVNDRVSLEE MRNFLSNVRD VERIVSRVEY NRSVPRDLVA LRETLEIIPK
     LNEILSNFGV FNKLAFPEEL VDLLRRAIED DPLGSPGEGK VIKRGFSPEL DEYRDLLEHA
     EERLKEFEEK ERERTGIQKL RVGYNQVFGY YIEVTKANLD KIPDDYERKQ TLVNSERFIT
     PELKEFETKI MAAKERIEEM EKELFKSVCE EVKKHKEVLL KLSEDLAKMD VLSTLAYDAI
     LYNYTKPVFS EDRLEIKGGR HPVVERFTQN FVENDIYMDN EKRFVVITGP NMSGKSTFIR
     QVGLISLMAQ IGSFVPAQKA ILPVFDRIFT RMGARDDLAG GRSTFLVEMN EMALILLKST
     EKSLVLLDEV GRGTSTQDGV SIAWAISEEL IKRGCKVLFA THFTELTELE KHFPQVQNKT
     ILVKEEGKNV IFTHKVVDGV ADRSYGIEVA KIAGIPDRVI NRAYEILERN FKNHTKKNGK
     SNRFSQQIPL FPV