ID   MUTS_THET2              Reviewed;         811 AA.
AC   P61671;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=TT_C0960;
OS   Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=262724;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX   PubMed=15064768; DOI=10.1038/nbt956;
RA   Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA   Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA   Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA   Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT   "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL   Nat. Biotechnol. 22:547-553(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017221; AAS81302.1; -; Genomic_DNA.
DR   RefSeq; WP_011173381.1; NC_005835.1.
DR   AlphaFoldDB; P61671; -.
DR   SMR; P61671; -.
DR   STRING; 262724.TT_C0960; -.
DR   EnsemblBacteria; AAS81302; AAS81302; TT_C0960.
DR   KEGG; tth:TT_C0960; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_2_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000592; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..811
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115159"
FT   BINDING         583..590
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   811 AA;  90616 MW;  73ECCE949334C748 CRC64;
     MGNMLKGEGP GPLPPLLQQY VELRDRYPDY LLLFQVGDFY ECFGEDAERL ARALGLVLTH
     KTSKDFTTPM AGIPIRAFDA YAERLLKMGF RLAVADQVEP AEEAEGLVRR EVTQLLTPGT
     LTQEALLPRE ANYLAAIATG DGWGLAFLDV STGEFKGTLL KSKSALYDEL FRHRPAEVLL
     APELRENEAF VAEFRKRFPV MLSEAPFEPQ GEGPLALRRA QGALLAYARA TQGGALSVRP
     FRLYDPGAFV RLPEASLKAL EVFEPLRGQD TLFGVLDETR TAPGRRLLQA WLRHPLLERG
     PLEARLDRVE RFVREGALRE GVRRLLFRLA DLERLATRLE LSRASPRDLA ALRRSLEILP
     ELKGLLGEEV GLPDLSGLLE ELRAALVEDP PLKVSEGGLI REGYDPDLDA LRRAHAEGVA
     YFLDLEAREK ERTGIPTLKV GYNAVFGYYL EVTRPYYEKV PQEYRPVQTL KDRQRYTLPE
     MKERERELYR LEALIKRREE EVFLALRERA RKEAEALREA ARILAELDVY AALAEVAVRH
     GYTRPRFGER LRIRAGRHPV VERRTAFVPN DLEMAHELVL VTGPNMAGKS TFLRQTALIA
     LLAQIGSFVP AEEAELPLFD GIYTRIGASD DLAGGKSTFM VEMEEVALVL KEATERSLVL
     LDEVGRGTSS LDGVAIATAL AEALHERRCY TLFATHYFEL TALALPRLKN LHVAAKEEEG
     GLVFYHQVLP GPASKSYGVE VAEMAGLPKE VVERARALLS AMAARREGAL EEVLERLLAL
     DPDRLTPLEA LRFLHELKAL ALGLPLGSMK G