ID   MUTS_THEVB              Reviewed;         874 AA.
AC   Q8DGS4;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=tlr2240;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000039; BAC09792.1; -; Genomic_DNA.
DR   RefSeq; NP_683030.1; NC_004113.1.
DR   RefSeq; WP_011058073.1; NC_004113.1.
DR   AlphaFoldDB; Q8DGS4; -.
DR   SMR; Q8DGS4; -.
DR   STRING; 197221.22295967; -.
DR   EnsemblBacteria; BAC09792; BAC09792; BAC09792.
DR   KEGG; tel:tlr2240; -.
DR   PATRIC; fig|197221.4.peg.2349; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..874
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115153"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          854..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         661..668
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   874 AA;  96694 MW;  A777F36F6096ECF2 CRC64;
     MSNDRPLTHS EAESSALRLG RNPGLQVRHD EVERSLLTPM LQHYAELKDA YPHALLLYRV
     GDFYETFFQD ACTVARELEL VLTGKEGGKE VGRVAMAGIP HHALERYCRT LIEKGYAIAI
     CDQVEDPAQA QGLVKREVTQ VFTPGTVLDT ELLQPRRNNF LAAVVLSGNH WGLAYADVST
     GEFCTTQGSD RADLVAELNR LQPAEILLPT EAPDINRVLR PGEGKDQLPP ELPPQWCYTL
     RSPEDFQAAA ARQRLCQRFQ VKSLEGFGCE HLPLALRAAG GLVAYLDETH RQQPVPLQNL
     STYSLQQYLF LDPQTRRNLE LTQTVRDGSF QGSLLWAIDR TATAMGGRLL RRWLLQPLLD
     IEEITARQDA IAELMANSSL RQSLHRHLQE IYDLERLAGR AGSGTANARD LAALRDSFRT
     LVSLAAVVAN TSSPYLQALA QLPPVIEQLA DTLSAALVDQ PPTSLSEGGI LRPGAYPELD
     QQRQQIEQDQ QWILNLEAQE RQRTGISTLK VGYTKVFGYY LSVSRAKLNQ VPDDYIRKQT
     LTNEERFITA ELKEREARLL AAQSHLFELE YQYFVQLREQ VAAQASTIRE IAAAVAAVDA
     LLGLAEVALY QGYCRPQLTR DRQLCIRGGR HPVVEQTLPA GFFVPNDTQL GTGADLMVLT
     GPNASGKSCY LRQVGLIQLL AQMGSYVPAT SATLGICDRI FTRVGAVDDL ATGQSTFMVE
     MNETANILNH AGDRSLVLLD EIGRGTATFD GLAIAWSVAE YLATILKSRT IFATHYHELN
     QLATLLPNVA NYQVVVKELP NEIIFLHQVK PGGADRSYGI EAGRLAGLPA VVIQRAREVM
     CQIEKHSRIT VGLRKSSMGD PPTAPEINQG ELPF