ID   MUTS_THIDA              Reviewed;         850 AA.
AC   Q3SJP0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Tbd_1159;
OS   Thiobacillus denitrificans (strain ATCC 25259).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Thiobacillaceae; Thiobacillus.
OX   NCBI_TaxID=292415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25259;
RX   PubMed=16452431; DOI=10.1128/jb.188.4.1473-1488.2006;
RA   Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA   Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT   "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT   anaerobic bacterium Thiobacillus denitrificans.";
RL   J. Bacteriol. 188:1473-1488(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000116; AAZ97112.1; -; Genomic_DNA.
DR   RefSeq; WP_011311671.1; NC_007404.1.
DR   AlphaFoldDB; Q3SJP0; -.
DR   SMR; Q3SJP0; -.
DR   STRING; 292415.Tbd_1159; -.
DR   PRIDE; Q3SJP0; -.
DR   EnsemblBacteria; AAZ97112; AAZ97112; Tbd_1159.
DR   KEGG; tbd:Tbd_1159; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008291; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..850
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224415"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   850 AA;  92213 MW;  BB928795823EFBA2 CRC64;
     MSIAPAAHTP MMQQYLGIKA QHPDMLLFYR MGDFYELFFE DAEKAARLLN ITLTTRGASA
     GSPIKMAGVP YHSAEQYLAR LLKLGESVVI AEQVGDPAAS KGPVERRVSR VVTPGTLTDA
     GLLDETRDAL IMAIAVAGDV LGVAWLNLAA GRFQVTELDR TALPALLARV RPAEILAHEH
     LDLAADCPVR RLDAWQFDAD GASKRLARQF GSCDLQGFGV AEMHCAIAAA GALLGYIETT
     QRTALPHLLS IRAERDSDFV LLDAATRRNL ELTETLRGDA APTLRSVLDT TCSGMGTRLL
     RHWLHHPLRD RAAVAARRDA IGVLAAAPDS AARLADLLKR CADVERIGGR IALKNARPRD
     LSGLRDTLAL LPELAAALPT DGARLAALRD AVAATPDVHA LLVRAIQPEP ASVLREGGVI
     ADGYDAELDE LRALTRDAGA FLLELETRER ARSGIATLKV EYNKVHGFYI EVGRAQAERV
     PDDYRRRQTL KNVERYLTPE LKAFEDKALS AQERALAREK ALFEALLDTL IPHVPNLLSI
     ASALAEIDVL ASQAERASTL RLCAPEFSDD PCIVIRGGRH PVVEAQVEHF IPNDVVLNRT
     RQMLLITGPN MGGKSTYMRQ VALITLMACC GLWVPAASAR IGAIDQIFTR IGASDDLAGG
     RSTFMVEMTE TANILHSATA DSLVLLDEIG RGTSTFDGLA LAWAVARHLV SATRAFTLFA
     THYFELTQLA QEYRQLANVH LDAKEHGADL VFLHAVEDGP ASQSYGIQVA RLAGVPGPVI
     HAARRRLREL EDAQLQPGPQ GDLFAAHLPR DEAPPHPALD QLRELDPDTL TPKAALDMLY
     ALKALTDSEP