ID   MUTS_TREDE              Reviewed;         891 AA.
AC   P61672;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=TDE_2603;
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G.,
RA   Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K.,
RA   Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E.,
RA   Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017226; AAS13120.1; -; Genomic_DNA.
DR   RefSeq; NP_973201.1; NC_002967.9.
DR   AlphaFoldDB; P61672; -.
DR   SMR; P61672; -.
DR   STRING; 243275.TDE_2603; -.
DR   EnsemblBacteria; AAS13120; AAS13120; TDE_2603.
DR   KEGG; tde:TDE_2603; -.
DR   PATRIC; fig|243275.7.peg.2461; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115162"
FT   REGION          827..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        827..845
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         639..646
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  99926 MW;  A7BC6F5BD76823D7 CRC64;
     MNKPQTPMMR QYLSIKAKYK DEILFFRLGD FYEMFFDEAV EVSRILNLTL TKRNDVPMCG
     IPYHAAKIYI ARLLRAGKKI AICEQVTEPV AGGLTERKVV EVITPGTVAE DDFLEQGSNN
     YLAAVYCSNK KTEGNSGFDY YAGLAYIDVT TGNFFATSFP KTDFKEQFLK EIGRINPKEI
     LIQQSIQNEF PALKQILSEF PSMMQNFYPD WSFNPDQAEK RLCSTFGTEN LKGFLLNTDS
     PEVPPAGLLL QYLEEISGRD ISHISGIKIY AESDFVSLDD STRKNLELLT NLRDNSPSYS
     LFESVNYTKT AMGTRLLRRR ISYPLRSKNE IDKRLDKVNS LFKDGKASAI IRETLSSILD
     IERLSGRIAM QKTHGKDLLA LKQSLNSVIR MGSLIEEKKL NFLQLNDEEK KLLTEIRDLL
     ENSIDDDCTI ALNDGKLIKK GFSKKVDTIK NIKENAHEIL EKYLDDERKK TGINNLKIKY
     NRMMGYFLEV SLGNISAVPD YFIRQRSLSN ADRFTTESLK QIEDNINNSE ERLIEAEKEV
     FDEVCTEIGS HHCFLQKLAE EVAELDVNQS FAQAAVLHAW TRPELCSDSG ILNITGGRHP
     VVENHLRAGD FVPNSIKLLS GENSNPEDET IPSFAVITGP NMAGKSTFLR QTALICLLAQ
     IGSFVPAEKA VLSPVDKIFC RVGATDNLAR GESTFLVEMI ETAYILNSAT RNSLVIMDEV
     GRGTSMEDGL AIAQAVSEHL LNTIKAKTLF ATHYHELTRL EHEKIINLKL DVLEAEGKIV
     FLKKVVHGAA GNSYGIHVAG LAGIPQSVLT RAENLLYMRS QFQKERTIQE ARPSAQGSEE
     KTPSSPAEKG LSLFPEEELI LNEILSTDPD ETAPIKALQL IASWKNRLSG K