ID   MUTS_TREPA              Reviewed;         900 AA.
AC   O83348;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=TP_0328;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE000520; AAC65315.1; -; Genomic_DNA.
DR   PIR; C71339; C71339.
DR   RefSeq; WP_010881776.1; NC_021490.2.
DR   AlphaFoldDB; O83348; -.
DR   SMR; O83348; -.
DR   IntAct; O83348; 11.
DR   STRING; 243276.TPANIC_0328; -.
DR   EnsemblBacteria; AAC65315; AAC65315; TP_0328.
DR   GeneID; 57878859; -.
DR   KEGG; tpa:TP_0328; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..900
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115163"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   900 AA;  99705 MW;  0972F3B6CBC088FE CRC64;
     MRSLASDTPL MRQYHAIRAQ HPDAVLFFRL GDFYEMFDSD ALHVSTLLGL TLTKRNGTPM
     CGVPVHTART HIARLLKHGK KVALCEQVSH PVPGELTQRK VIEIISPGTA VEDDFLSQGF
     SQYLATVCAS DATVAFSYLE VSTGAFFITS FPRAEAADAL QKEFGRVQPS EVLLSASVLR
     SLPELAAILS LYPRLVRTTG ADALFNPEHT KNRLHHCFRT RNLDCLTLLP HSPDLAAAGA
     LIAYLEETTR HPLSHVSAIT RYHIHDFVEI DDATRKNLEI LQNLHDSTHA HSLFETLNYT
     HTAMGTRLLR YWLHHPLRSQ EEIQKRLSAV VFFHHRPHIL KTLRATLSCV RDVERLVARV
     ALEKAHGRDL LALKESLRAI LTFRSLERES PFPPDLLPSE GDTPVLQELY GLLEQSIKED
     CPVTLSDGNL IKRGFSASLD ELHRVRDNAN EILKQYLAEE RERTGIGTLK MKYNRMLGHF
     LEVSKGHLSA VPAHFIRRRS LSNADRFTTE QLSELEAKLA RAREGLVSFE QELFADIRRT
     VCSHTQLLRT NAARVAQLDV LQSFAHAALQ HGWSQPVFIK DGALRITGGR HPVVELHLPS
     GEFVPNDLTL SSSEHAVLPR FALITGPNMA GKSTFLRQTA LICLIAQVGS FVPAEKAELT
     PVDRIFCRVG AADNLARGES TFLVEMSETA HILRAATRDS LVIMDEVGRG TATEDGLSIA
     QAVSEYLLHH VRAKTLFATH YHELSRLAHP QLEHLKLDVL ETDNTIVFLK KVTPGSCGSS
     YGIYVARLAG LPESVLARAC ELLKQLQQRA GSAPRASAAH EADAVAQTEA VHAHKAASKP
     CAQRVSADLF TQEELIGAEI ASLNPDAITP LEALTLIARW KRSLRGSATQ QSSAMTKRKG