ID   MUTS_TRIEI              Reviewed;         901 AA.
AC   Q10YG4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Tery_3645;
OS   Trichodesmium erythraeum (strain IMS101).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales;
OC   Microcoleaceae; Trichodesmium.
OX   NCBI_TaxID=203124;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMS101;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Richardson P.;
RT   "Complete sequence of Trichodesmium erythraeum IMS101.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000393; ABG52710.1; -; Genomic_DNA.
DR   RefSeq; WP_011613042.1; NC_008312.1.
DR   AlphaFoldDB; Q10YG4; -.
DR   SMR; Q10YG4; -.
DR   STRING; 203124.Tery_3645; -.
DR   EnsemblBacteria; ABG52710; ABG52710; Tery_3645.
DR   KEGG; ter:Tery_3645; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..901
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335240"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         679..686
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   901 AA;  100977 MW;  93BA928B06B78E9B CRC64;
     MKYSASTSTP KSAQPKEEEL ENSLPTNADY SKIDVSKLSE MMQRYVEVKQ QYSHALLLFR
     VGDFFECFFQ DAVTIAQELE LVQTTKHAGK EIGRVPMTGV PHHAVEKYAT FLVEKGYAVV
     VCDQVEDSAI AKKENRQVKR EITRILTPGT LTDDGMLKAR YNNYLAAVVI AKNYWGLAYT
     DISTGEFLTT QTEGLDQLTQ ELMRLQPSEV LFPTKAPDIG FMLRPGERSD HLPEYLPHSF
     CYSLRPQQPF SLGEAKERLL MKFQLASLEG LGCERLPLGV RAAGGLLEYL EETQKENQVP
     LQRLRSYTLA DFLILDHQSR RNLEITQTVR DGSYQGSLLS VVDKTSTAMG GRALRRWLQQ
     PLLSLKGIRA RHDTIDELIQ NNDLRQDIQR VLRQIYDLER LTGRTGAGTA NARDLVFLAD
     SLTKLPELST FVSQGNSPYL KVLQKIPPIL QELGKKIHSN LVESPSQKLK EGGLIRPGIN
     ERLDEMRKLA EEDQKWIASL ETTERERTGI PNLKVGYNKA FGYYISISKS KANLAPDDYT
     RKQTLTNEER YITEELKERE VRILTAQDDL NELEYDIFVD LRNEVGEYAE EIRNVSRAVA
     ALDILCGLAD VAIYQNYVRP TMVDSRELKI IEGRHPVVEK YLPAGFFVPN TAILGSKNLE
     KNNSGITPYS APDLIILTGP NASGKSCYLR QVGLIQLMAQ IGSFVPASSA VLGVSDRIFT
     RVGAVDDLAT GQSTFMVEMN ETANILNHAT EKSLVLLDEI GRGTATFDGI SIAWSVAEYL
     ATEILSRTIF ATHYHELNEL SSILDNVANY QVTVKELPDK IVFLHQVQPG GADKSYGIEA
     GRLAGLPDSV IARARQVMQQ IENHSKIAIG LRKGINKKEE EEIITVEQLD IFSEEFGDSL
     L