ID   MUTS_TRIL1              Reviewed;         872 AA.
AC   B3E6P2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Glov_1145;
OS   Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) (Geobacter
OS   lovleyi).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Trichlorobacter.
OX   NCBI_TaxID=398767;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1151 / DSM 17278 / SZ;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T.,
RA   Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Sung Y., Fletcher K.E.,
RA   Ritalahti K.M., Loeffler F.E., Richardson P.;
RT   "Complete sequence of chromosome of Geobacter lovleyi SZ.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001089; ACD94867.1; -; Genomic_DNA.
DR   RefSeq; WP_012469216.1; NC_010814.1.
DR   AlphaFoldDB; B3E6P2; -.
DR   SMR; B3E6P2; -.
DR   STRING; 398767.Glov_1145; -.
DR   EnsemblBacteria; ACD94867; ACD94867; Glov_1145.
DR   KEGG; glo:Glov_1145; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_0_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002420; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118684"
FT   BINDING         623..630
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  96756 MW;  74D5A30A74CA2846 CRC64;
     MSSALQTPMM RQYLEIKAQH PESILFFRMG DFYEMFLDDA LVASRILDIT LTSRNKNSAD
     EIPFCGVPFH SAQPYIARLV EAGYRVAVCE QIEDPKQTKG LVKRDVVKVV TPALVTESES
     LTPDENSFLL ALCSSGQRWG CAWLDLSTGE FLTANSDNLA GAATLLASIA PRELLLPDQL
     RRDLPPELAL VAGDRPRAAV ADWVLDKDYC SKLICSQFGV ASPEMLGLAV TELSEALLAT
     GMVLHYLQEN RHATLPHLRD LTIVRQNDHL ALDPATRRNL ELTATMTDNK KSGSLLGCLD
     RTATAMGART LKQWLSYPLV QVAPIRRRLE AVEELKENPA LQDQLREQLK GVHDLERLNG
     RVSMAGAGGR DLRSLHDSLE QVPQIRLALT EATAPLLRDL TEELDPLQDI RSLINQAIAP
     APPFSLREGG IIADGYHAEL DELRAISREG KGYIARMEAQ ERDRTGISSL KIRYNKVFGY
     YIEVTKSNLS SVPDNYIRRQ TIATGERYIT EELKSYEEKV LGAEDRICEL EYTLFQEVRE
     RTAAQGGRVS RTASALASLD VLASLALVAQ ERDYCKPVVD DGDTLEIIEG RHPVVEAMNL
     GERFVPNDTR LDQEQHQLLM ITGPNMAGKS TYMRQVALIT LMAQVGSFVP ASRATIGIAD
     QIFTRVGAGD NLARGQSTFM VEMMETAHIL RSATTKSLVV LDEIGRGTST FDGLSIAWAV
     AEYLHDTNHC KARTLFATHY HELADLAATR EGITNLTVAV KEWNDQVIFL RTIIPGAASH
     SYGIQVARLA GMPRNVIERA KEVLKTLEEG EFEQGSPRLS KSSIAPPRKE TAQFTLFEQQ
     GDLLRERLKK LNISVMTPLE ALNLLDELKK MA