ID   MUTS_TRIV2              Reviewed;         854 AA.
AC   Q3M892;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ava_3186;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000117; ABA22794.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3M892; -.
DR   SMR; Q3M892; -.
DR   STRING; 240292.Ava_3186; -.
DR   PRIDE; Q3M892; -.
DR   EnsemblBacteria; ABA22794; ABA22794; Ava_3186.
DR   KEGG; ava:Ava_3186; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_3; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335110"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         658..665
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95017 MW;  2BD24032F09A7AC4 CRC64;
     MTASDIQPTE PHTPPTPHAD TRLVDRTKLS KMYQHYVEVK DKYPHALLLY RVGDFFETFF
     QDAVTVAREL ELVLTSKHGG EVGRVAMTGV PHHAWERYTT QLVEKGYAVV ICDQVEDASE
     AVGLVRREVT RILTPGTLLE EGMLKSSRNN YLAAVVITSN HWGLAYADIS TGEFLTTQDS
     DLERLTQELM RLQPSEVLVP TNAPDLGTLL RPGETSPHLP ECLPPSFCYS LRSQQPFSQA
     EARSTLLQRF KVRSLEGLGC DHLPLAVRAA GGLLEYVEDT QKAGQVSLQR LRTYTITDYL
     IVDNQTRRNL EITQTVRDGT FHGSLLWALD KTSTAMGSRA LRRWLLQPLL DIKGISSRQD
     TIQELVTNTR LRQDLRHLLR QIYDLERLTG RASSGTANAR DLVALADSLS RLPELANLVI
     DAHSPFLKAL QKVPPILEEL AQKIHAHLVE SPPLHLKEGG LIRPGVNPLL DERKATVEAD
     HQWIANLEVD ERARTGIPLL KVGFNETFGY YISISRAKAD QVPANYIRKQ TLKNEERYIT
     PELKEREARI LTARDDLHKL EYEVFVTLRE EVGEQAEAIR HLSRAVAAAD VLCGLAELAV
     YQGYCRPEMV NGREIAIIDG RHPVVEQSLP AGFFVPNSTQ LGSNEETHQL PDLIILTGPN
     ASGKSCYLRQ VGLIQLMAQI GSFVPAKSAR LGICDRIFTR VGAVDDLATG QSTFMVEMNE
     TANILNHATS RSLVLLDEIG RGTATFDGLS IAWAVAEYIA TEIRSRTIFA THYHELNELA
     GMLPNVANYQ VTVKELPDQI IFLHQVQPGG ADKSYGIEAG RLAGLPTVVI QRAKQVMGQI
     EKHSKIAMGL QNLD