ID   MUTS_VARPS              Reviewed;         885 AA.
AC   C5CTL8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Vapar_3589;
OS   Variovorax paradoxus (strain S110).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=543728;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S110;
RX   PubMed=21183664; DOI=10.1128/jb.00925-10;
RA   Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G.,
RA   O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C.,
RA   Ovchinnikova G., Goodwin L., Han C.;
RT   "Complete genome sequence of the metabolically versatile plant growth-
RT   promoting endophyte, Variovorax paradoxus S110.";
RL   J. Bacteriol. 193:1183-1190(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001635; ACS20206.1; -; Genomic_DNA.
DR   RefSeq; WP_012748684.1; NC_012791.1.
DR   AlphaFoldDB; C5CTL8; -.
DR   SMR; C5CTL8; -.
DR   STRING; 543728.Vapar_3589; -.
DR   EnsemblBacteria; ACS20206; ACS20206; Vapar_3589.
DR   GeneID; 45057847; -.
DR   KEGG; vap:Vapar_3589; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..885
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202746"
FT   BINDING         640..647
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   885 AA;  95591 MW;  18CCCCA934149113 CRC64;
     MKTTTAQPSP STSDFSGHTP MMAQYLGLKA NHPDTLLFYR MGDFYELFWA DAEKAARLLD
     ITLTQRGQSA GQPVVMCGVP FHAVDTYLAR LIKLGESVAI CEQVGEVGAS KGPVERKVVR
     VVTPGTLTDS ELLNDKSESL LLAVHAGTRN FCGLAWLSVT GAELRLAECP ADALEAWIAR
     IAPSELLYSA EVTPAFEQRL KAARAATPFT LSIRPAWQFD GGLGERKLSE QMGSNSLAAW
     NAESLANAHA AAAALLGYAE HTQGRALSHV QRLSVERDGD LVELPPTTRR NLELVQTLRG
     EDSPTLFSLL DTCMTGMGSR LLKRWLLSPR RDRGEAQARL EAIAALQSTV LGGTAAPWRT
     LREQLKNTSD VERIAARIAL RQVRPRELLA LRLALAKAEQ LAPALPASGE LLGGIIERLA
     PPSGCADLLA SAIKPDPSAL VRDGGVIATG HDAELDELRA ISENCDDFLL KLEVSERERT
     GISNLRVQFN RVHGFYIEVT QSALSKVPDN YRRRQTLKNA ERFITPELKA FEDKALSAQD
     RALAREKWLY EQLLDALQPS VPALTQLAGA IATLDALCAL AERSHTLHWR APSFVSHPCI
     EIQQGRHPVV EARLAEKSSG GFIANDTQLG PQQRMQVITG PNMGGKSTYM RQVAIIVLLA
     SIGSHVPAAA CRLGPIDAIH TRIGAADDLA NAQSTFMLEM TEAAQILHSA TAQSLVLMDE
     IGRGTSTFDG LALAAGIAAQ LHDRSKAFTL FATHYFELTE FPATHHCAVN MHVSATEAGR
     DIVFLHEMQP GPASKSYGIQ VARLAGMPAA VVNHARQALE ALESQHAQTR AQVDLFAPPP
     AAETPMASAV ESALAALDPD AMTPREALDA LYALQKLNTR ERGAA