ID   MUTS_VEREI              Reviewed;         871 AA.
AC   A1WRJ3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Veis_4552;
OS   Verminephrobacter eiseniae (strain EF01-2).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Verminephrobacter.
OX   NCBI_TaxID=391735;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EF01-2;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
RT   "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000542; ABM60250.1; -; Genomic_DNA.
DR   RefSeq; WP_011812234.1; NC_008786.1.
DR   AlphaFoldDB; A1WRJ3; -.
DR   SMR; A1WRJ3; -.
DR   STRING; 391735.Veis_4552; -.
DR   EnsemblBacteria; ABM60250; ABM60250; Veis_4552.
DR   KEGG; vei:Veis_4552; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000374; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335241"
FT   REGION          830..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         630..637
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  94974 MW;  AC46B4892A490D8E CRC64;
     MSAPLEHHTP MMAQYLALKG GYPETLLFYR MGDFYELFYA DAEKAARLLN ITLTQRGQSG
     GQTVVMAGVP FHALENYLTR LIKLGESVAI AEQVGEVGAA KGPLERKVVR VITPGTLTDT
     ELLSDKAESL LLSLHQAARA RCGLAWLSVT QGRVHLAECA HDELGAWLAR VAPSEIIYSA
     GVTQRFEQQL QALRQSGAFD CPMRTRPDWQ FDQALGERKL LEHLGAASLQ AWDAQDLGAA
     QAAAAGLLAY AEHTQGRALT HVHSVQAQRG DELIDLPGST RRNLELVKTL RGDDAPTLLS
     LLDNCMTGMG SRLLKTWLLE PHRERHQARQ RLSASTALRG AAAGAGPWAT LREQIKGASD
     VERITARIAL RQVRPRELPG LVKTLQKAQL LAQHGQIPEP YLMQIFDQLH PPEGCAELLQ
     AAIAEEPAAL VREGGVIATG FDAELDELRA LQTDCDGFLL DLETREKART GIANLRVQFN
     KVHGFYIEVT SSNLERVPAD YRRRQTLKNA ERFITPELKA FEDKALSANE RALVREKWLY
     EQILDRLQPH VPALTRLAQA LATLDVLCTL AERSLTLNWC APQFVSEPCI EIEGGRHPVV
     EARLAETASG SFIANHTRLN ANTRMQLITG PNMGGKSTYM RQVALIVLLA SIGSHVPASS
     CRLGPIDAIH TRIGAADDLA NAQSTFMLEM TEAAHILHAA TAHSLVLMDE IGRGTSTFDG
     LALASGIATH LHDKTRAFTL FATHYFELTD LPAKARHAIN MHVSATESGA DIVFLHEIQP
     GPASRSYGIQ VAKLAGMPPP VLHHARRTLA ALEERAGAGQ LQVDLFAAPK EEPESKSASP
     VEAALAGINP DALSPREALD ALYQLKRMAG K