ID   MUTS_VIBA3              Reviewed;         853 AA.
AC   B7VK59;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VS_2598;
OS   Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=575788;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LGP32;
RA   Mazel D., Le Roux F.;
RT   "Vibrio splendidus str. LGP32 complete genome.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; FM954972; CAV19791.1; -; Genomic_DNA.
DR   RefSeq; WP_012604771.1; NC_011753.2.
DR   AlphaFoldDB; B7VK59; -.
DR   SMR; B7VK59; -.
DR   STRING; 575788.VS_2598; -.
DR   EnsemblBacteria; CAV19791; CAV19791; VS_2598.
DR   KEGG; vsp:VS_2598; -.
DR   PATRIC; fig|575788.5.peg.3847; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000009100; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118702"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  94790 MW;  5924AFC159A79C52 CRC64;
     MKADQKHTPM MQQYLKLKAE NPEILLFYRM GDFYELFYDD AKKASQLLDI SLTKRGSSNG
     EPIPMAGVPY HAVEGYLAKL VQLGESVAIC EQIGNPATSK GPVERAVVRI VTPGTVTDEA
     LLSERIDNLI ASIYHHNGKF GYATLDITSG RFQLCEPETE EAMAAELQRT SPRELLFPED
     FEPVNLMASR NGNRRRPVWE FELDTAKQQL NKQFGTRDLV GFGVEGAKLG LCAAGCLIQY
     VKDTQRTALP HIRSLTMDKQ DHSVILDAAT RRNLEITQNL GGGTDNTLAE VLDHTATAMG
     SRMLKRWLHQ PMRNISALDQ RLDAIGEMKD LALFTELQPT LKQIGDIERI LARLALRSAR
     PRDMARLRQA MEYLPELAET LTQLKHPYLT QLAQYASPVD EVSELLERAI KENPPVVIRD
     GGVIAEGYNA ELDEWRDLAA GATEFLDKLE QEERERHGID TLKVGYNNVH GFFIQVSRGQ
     SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLSSKSKAL AIEKKLWDEL FDLLLPYLER
     LQNIASSVSQ LDVLQNLAER ADTLDYCRPT MTESAGVQIQ AGRHPVVEQV MDEPFIANPI
     DLNDQRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGCYVP AESATIGSID RIFTRIGASD
     DLASGRSTFM VEMTETANIL HNATPNSLVL MDEIGRGTST YDGLSLAWAS AEWLANQINA
     MTLFATHYFE LTELPNQIPT LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
     PKAVIKNARA KLTQLEALSI DSPTSKPSGV DIANQLSLIP EPSEVEQALA NVDPDDLTPR
     QALEELYRLK KLL