ID   MUTS_VIBC1              Reviewed;         853 AA.
AC   A7MTT8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=VIBHAR_03515;
OS   Vibrio campbellii (strain ATCC BAA-1116).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=2902295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1116 / BB120;
RG   The Vibrio harveyi Genome Sequencing Project;
RA   Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C.,
RA   Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K.,
RA   Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J.,
RA   Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000789; ABU72451.1; -; Genomic_DNA.
DR   RefSeq; WP_012128906.1; NC_022269.1.
DR   AlphaFoldDB; A7MTT8; -.
DR   SMR; A7MTT8; -.
DR   EnsemblBacteria; ABU72451; ABU72451; VIBHAR_03515.
DR   KEGG; vha:VIBHAR_03515; -.
DR   PATRIC; fig|338187.25.peg.2695; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008152; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008116"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  94836 MW;  954963C0D40BA6F6 CRC64;
     MKAEQKHTPM MQQYLKLKAE NPEILLFYRM GDFYELFYDD AKRASQLLDI SLTKRGASAG
     EPIPMAGVPF HAVEGYLAKL VQLGESVAIC EQIGDPATSK GPVERKVVRI VTPGTVTDEA
     LLSERIDNLI AAIYQHNGKF GYATLDVTSG RFQLVEPETE EAMAAELQRT APRELLFPED
     FEAVHLMSNR NGNRRRPVWE FELDTAKQQL NQQFGTRDLV GFGVEHASLG LCAAGCLIQY
     VKDTQRTALP HIRSLTFDRQ DHSVILDAAT RRNLELTQNL SGGTDNTLAE VLDHCATPMG
     SRMLKRWLHQ PMRCVDTLNN RLDAIGEIKD QSLFTDIQPI FKQIGDIERI LARLALRSAR
     PRDMARLRHA MQQLPELEAV TSSLAHPYLK KLAQFAAPMD EVCDLLERAI KENPPVVIRE
     GGVIAEGYNA ELDEWRKLAD GATEYLEKLE ADERERHGID TLKVGYNAVH GFFIQVSRGQ
     SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL AVEKKLWEEL FDLLMPNLEK
     IQNLASAISQ LDVLQNLAER ADSLDYCRPT LNKEAGISIQ AGRHPVVEQV TSEPFIANPI
     ELSSNRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGSYVP AESAHIGSLD RIFTRIGASD
     DLASGRSTFM VEMTETANIL HNATKNSLVL MDEIGRGTST YDGLSLAWAS AEWLATQIGA
     MTLFATHYFE LTELPNLLPN LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
     PKPVIKNARN KLSQLEQLGQ GNDSARPSTV DVANQLSLIP EPSDVEQALS NIDPDDLTPR
     QALEELYRLK KML