ID   MUTS_VIBCM              Reviewed;         862 AA.
AC   C3LS25;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VCM66_0493;
OS   Vibrio cholerae serotype O1 (strain M66-2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=579112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M66-2;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001233; ACP04818.1; -; Genomic_DNA.
DR   RefSeq; WP_001894770.1; NC_012578.1.
DR   AlphaFoldDB; C3LS25; -.
DR   SMR; C3LS25; -.
DR   EnsemblBacteria; ACP04818; ACP04818; VCM66_0493.
DR   KEGG; vcm:VCM66_0493; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001217; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118701"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  96327 MW;  98882509B7140531 CRC64;
     MMKSNASPSE SLSHHTPMMQ QYLRLKAENP DILLFYRMGD FYELFYDDAK RASELLDISL
     TKRGASAGEP IPMAGVPFHA VEGYLAKLVQ MGESVAICEQ IGDPATSKGP VERKVVRIVT
     PGTVTDEALL SERVDNLIAA IYHHNGRFGY ATMDITSGRF QLSEPQTEEE MAAELQRTSP
     RELLFPEDFS PVHLMASRQG NRRRPIWEFE LDTAKQQLNQ QFGTRDLVGF GVEQAKLGLC
     AAGCLIQYVK DTQRTALPHI RSLTWDRQDQ SVILDAATRR NLELTHNLAG GTDNTLAEVL
     DHCATPMGSR MLKRWIHQPM RDNATLNQRL DAITELKETA LYGELHPVLK QIGDIERILA
     RLALRSARPR DLARLRHAMQ QLPELHSVMS ELKQPHLTEL RTHAEPMDEL CDLLERAIKE
     NPPVVIRDGG VIADGYSAEL DEWRDLANGA TEFLERLEAE ERDRHGIDTL KVGYNNVHGF
     YIQVSRGQSH LVPPHYVRRQ TLKNAERYII EELKQHEDKV LNSKSRALAL EKQLWEELFD
     LLMPHLEQLQ QLAASVAQLD VLQNLAERAE NLEYCRPTLV QEAGIHIQGG RHPVVERVMN
     EPFIANPIEL NPQRRMLIIT GPNMGGKSTY MRQTALIALM AHIGSYVPAE SASIGPLDRI
     FTRIGASDDL ASGRSTFMVE MTETANILHN ATRNSLVLMD EIGRGTSTYD GLSLAWASAE
     WLAKEIGAMT LFATHYFELT ELPNVLPHLA NVHLDAVEHG DGIAFMHAVQ EGAASKSYGL
     AVAGLAGVPK PVIKNARAKL QQLELLSSQP AETRKPSRVD IANQLSLIPE PSAVEQALAG
     VDPDQLTPRQ ALDMLYQLKK LL